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Human Pancreatic β ...
Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks
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- Akerman, Ildem (author)
- Imperial College London,CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM),Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)
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- Tu, Zhidong (author)
- Icahn School of Medicine at Mount Sinai
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- Beucher, Anthony (author)
- Imperial College London
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- Rolando, Delphine M Y (author)
- Imperial College London
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- Sauty-Colace, Claire (author)
- Paris-Sorbonne University
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- Benazra, Marion (author)
- Paris-Sorbonne University
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- Nakic, Nikolina (author)
- Imperial College London
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- Yang, Jialiang (author)
- Icahn School of Medicine at Mount Sinai
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- Wang, Huan L. (author)
- Icahn School of Medicine at Mount Sinai
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- Pasquali, Lorenzo (author)
- Institute for Health Science Research Germans Trias i Pujol (IGTP),CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM),Josep Carreras Leukaemia Research Institute (IJC)
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- Moran, Ignasi (author)
- Imperial College London
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- Garcia-Hurtado, Javier (author)
- Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)
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- Castro, Natalia (author)
- Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)
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- Gonzalez-Franco, Roser (author)
- Imperial College London
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- Stewart, Andrew F. (author)
- Icahn School of Medicine at Mount Sinai
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- Bonner, Caroline (author)
- National Institute for Health and Medical Research, France
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- Piemonti, Lorenzo (author)
- San Raffaele Scientific Institute
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- Berney, Thierry (author)
- University of Geneva
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- Groop, Leif (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Kerr-Conte, Julie (author)
- National Institute for Health and Medical Research, France
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Pattou, Francois (author)
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- Argmann, Carmen (author)
- Icahn School of Medicine at Mount Sinai
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- Schadt, Eric (author)
- Icahn School of Medicine at Mount Sinai
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- Ravassard, Philippe (author)
- Paris-Sorbonne University
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- Ferrer, Jorge (author)
- Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Imperial College London,CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English 12 s.
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In: Cell Metabolism. - : Elsevier BV. - 1550-4131. ; 25:2, s. 400-411
- Related links:
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http://dx.doi.org/10... (free)
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http://www.cell.com/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cell gene regulation and diabetes, the function of β cell lncRNAs remains largely unknown. In this study, we investigated the function of β cell-specific lncRNAs and transcription factors using transcript knockdowns and co-expression network analysis. This revealed lncRNAs that function in concert with transcription factors to regulate β cell-specific transcriptional networks. We further demonstrate that the lncRNA PLUTO affects local 3D chromatin structure and transcription of PDX1, encoding a key β cell transcription factor, and that both PLUTO and PDX1 are downregulated in islets from donors with type 2 diabetes or impaired glucose tolerance. These results implicate lncRNAs in the regulation of β cell-specific transcription factor networks.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- chromatin
- CRISPR interference
- diabetes
- lncRNAs
- long noncoding RNAs
- pancreatic islets
- PDX1
- PLUTO
- transcriptional networks
- type 2 diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Akerman, Ildem
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Tu, Zhidong
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Beucher, Anthony
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Rolando, Delphin ...
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Sauty-Colace, Cl ...
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Benazra, Marion
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show more...
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Nakic, Nikolina
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Yang, Jialiang
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Wang, Huan L.
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Pasquali, Lorenz ...
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Moran, Ignasi
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Garcia-Hurtado, ...
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Castro, Natalia
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Gonzalez-Franco, ...
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Stewart, Andrew ...
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Bonner, Caroline
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Piemonti, Lorenz ...
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Berney, Thierry
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Groop, Leif
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Kerr-Conte, Juli ...
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Pattou, Francois
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Argmann, Carmen
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Schadt, Eric
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Ravassard, Phili ...
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Ferrer, Jorge
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Cell Metabolism
- By the university
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Lund University