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Fluorescently labeled xylosides offer insight into the biosynthetic pathways of glycosaminoglycans
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- Mastio, Roberto (author)
- Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Frankel Willén, Daniel (author)
- Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Söderlund, Zackarias (author)
- Lund University,Lunds universitet,Kansli för experimentell medicinsk vetenskap,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department Office of Experimental Medical Science,Department of Experimental Medical Science,Faculty of Medicine
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- (creator_code:org_t)
- 2021
- 2021
- English 10 s.
- In: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 11:60, s. 38283-38292
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Five novel xylosides tagged with the fluorescent probe Pacific Blue™ were synthesized and found to act as substrates for β4GalT7, a bottleneck enzyme in the biosynthetic pathways leading to glycosaminoglycans. By confocal microscopy of A549 cells, we showed that the xylosides were taken up by the cells, but did not enter the Golgi apparatus where most of the glycosaminoglycan biosynthesis occurs. Instead, after a possible double galactosylation by β4GalT7 and β3GalT6, the biosynthesis was terminated. We hypothesize this is due to the charge of the fluorescent probe, which is required for fluorescent ability and stability under physiological conditions.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
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