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Plasma 25-Hydroxyvi...
Plasma 25-Hydroxyvitamin D concentration and risk of islet autoimmunity
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- Norris, Jill M. (författare)
- Colorado School of Public Health
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- Lee, Hye Seung (författare)
- University of South Florida
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- Frederiksen, Brittni (författare)
- Colorado School of Public Health
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- Erlund, Iris (författare)
- Finnish National Institute for Health and Welfare
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- Uusitalo, Ulla (författare)
- University of South Florida
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- Yang, Jimin (författare)
- University of South Florida
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- Lernmark, Åke (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Simell, Olli (författare)
- Turku University Hospital
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- Toppari, Jorma (författare)
- Turku University Hospital,University of Turku
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- Rewers, Marian (författare)
- University of Colorado
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- Ziegler, Anette G. (författare)
- German Diabetes Research Institute
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- She, Jin Xiong (författare)
- Medical College of Georgia
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- Onengut-Gumuscu, Suna (författare)
- University of Virginia
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- Chen, Wei Min (författare)
- University of Virginia
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- Rich, Stephen S. (författare)
- University of Virginia
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- Sundvall, Jouko (författare)
- Finnish National Institute for Health and Welfare
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- Akolkar, Beena (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Krischer, Jeffrey (författare)
- University of South Florida
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- Virtanen, Suvi M. (författare)
- University of Tampere
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- Hagopian, William (författare)
- Pacific Northwest Research Institute
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(creator_code:org_t)
- 2017-10-23
- 2018
- Engelska 9 s.
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 67:1, s. 146-154
- Relaterad länk:
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http://dx.doi.org/10...
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https://diabetes.dia...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- We examined the association between plasma 25- hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We conducted a risk set sampled nested casecontrol study of 376 IA case subjects and up to 3 control subjects per case subject. 25(OH)D concentrationwas measured on all samples prior to, and including, the first IA positive visit. Nine polymorphisms in VDR, CYP24A, CYP27B1, GC, and RXRA were analyzed as effect modifiers of 25(OH)D. Adjusting for HLA-DR-DQ and ancestry, higher childhood 25(OH)D was associated with lower IA risk (odds ratio = 0.93 for a 5 nmol/L difference; 95% CI 0.89, 0.97). Moreover, this association was modified by VDR rs7975232 (interaction P = 0.0072), where increased childhood 25(OH)D was associated with a decreasing IA risk based upon number of minor alleles: 0 (1.00; 0.93, 1.07), 1 (0.92; 0.89, 0.96), and 2 (0.86; 0.80, 0.92). Vitamin D and VDR may have a combined role in IA development in children at increased genetic risk for type 1 diabetes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Diabetes
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Norris, Jill M.
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Lee, Hye Seung
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Frederiksen, Bri ...
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Erlund, Iris
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Uusitalo, Ulla
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Yang, Jimin
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visa fler...
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Lernmark, Åke
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Simell, Olli
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Toppari, Jorma
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Rewers, Marian
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Ziegler, Anette ...
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She, Jin Xiong
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Onengut-Gumuscu, ...
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Chen, Wei Min
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Rich, Stephen S.
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Sundvall, Jouko
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Akolkar, Beena
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Krischer, Jeffre ...
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Virtanen, Suvi M ...
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Hagopian, Willia ...
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Diabetes
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