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Investigation of mo...
Investigation of molecular alterations of AKT-3 in triple-negative breast cancer
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- O'Hurley, Gillian (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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Daly, Etain (author)
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O'Grady, Anthony (author)
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Cummins, Robert (author)
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Quinn, Cecily (author)
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Flanagan, Louise (author)
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Pierce, Aisling (author)
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Fan, Yue (author)
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Lynn, Miriam A. (author)
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Rafferty, Mairin (author)
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Fitzgerald, Dara (author)
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- Pontén, Fredrik (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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Duffy, Michael J. (author)
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- Jirström, Karin (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Kay, Elaine W. (author)
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Gallagher, William M. (author)
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(creator_code:org_t)
- 2013-12-12
- 2014
- English.
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In: Histopathology. - : Wiley. - 0309-0167 .- 1365-2559. ; 64:5, s. 660-670
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Aims Triple-negative breast cancer (TNBC) is responsible for a disproportionate number of breast cancer (BC) deaths, owing to its intrinsic aggressiveness and a lack of treatment options, especially targeted therapies. Thus, there is an urgent need for the development of better targeted treatments for TNBC. Molecular alteration of AKT-3 was previously reported in oestrogen receptor (ER)-positive BC. AKT-3 has also been suggested to play a role in hormone-unresponsive BC. The aim of this study was to investigate molecular alterations of AKT-3 in TNBC, to perform associated survival analysis, and to compare these findings with the incidence of AKT-3 molecular alterations in ER-positive BC. Results Our study revealed AKT-3 amplification and deletions in 11% (9/82) and 13% (11/82) of TNBCs, respectively. In contrast, 1% (2/209) of ER-positive BCs were found to have AKT-3 amplifications and deletions. A higher prevalence of AKT-3 copy number gains was observed in TNBC [26% (21/82)] than in ER-positive BC [9% (19/209)]. AKT-3 amplification together with Akt-3 protein expression was negatively associated with recurrence-free survival in TNBC. Furthermore, a negative association between high AKT-3 copy number and recurrence-free survival was observed. Conclusion AKT-3 amplification could represent a potentially relevant oncogenic event in a subset of TNBCs that may, in turn, select cells sensitive to Akt-3 inhibitors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- fluorescence in-situ hybridization
- AKT-3
- ER-positive breast cancer
- triple-negative breast cancer
- molecular alterations
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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O'Hurley, Gillia ...
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Daly, Etain
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O'Grady, Anthony
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Cummins, Robert
-
Quinn, Cecily
-
Flanagan, Louise
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show more...
-
Pierce, Aisling
-
Fan, Yue
-
Lynn, Miriam A.
-
Rafferty, Mairin
-
Fitzgerald, Dara
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Pontén, Fredrik
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Duffy, Michael J ...
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Jirström, Karin
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Kay, Elaine W.
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Gallagher, Willi ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Histopathology
- By the university
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Lund University
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Uppsala University