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Right precordial-di...
Right precordial-directed electrocardiographical markers identify arrhythmogenic right ventricular cardiomyopathy in the absence of conventional depolarization or repolarization abnormalities
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- Cortez, Daniel (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden; Penn State Milton S Hershey Medical Centre, PA 17033 USA
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- Svensson, Anneli (author)
- Linköpings universitet,Linköping University,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Carlson, Jonas (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Graw, Sharon (author)
- University of Colorado Denver AMC, CO USA
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- Sharma, Nandita (author)
- Penn State Milton S Hershey Medical Centre, PA 17033 USA
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- Brun, Francesca (author)
- University of Colorado Denver AMC, CO USA; Osped Riuniti, Italy; University of Trieste, Italy,University of Colorado
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- Spezzacatene, Anita (author)
- University of Colorado Denver AMC, CO USA; Osped Riuniti, Italy; University of Trieste, Italy,University of Trieste
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- Mestroni, Luisa (author)
- University of Colorado Denver AMC, CO USA; Osped Riuniti, Italy; University of Trieste, Italy,University of Trieste
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- Platonov, Pyotr G. (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden; Skåne University Hospital, Sweden
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(creator_code:org_t)
- 2017-10-13
- 2017
- English 10 s.
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In: BMC Cardiovascular Disorders. - : Springer Science and Business Media LLC. - 1471-2261. ; 17:1
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Abstract
Subject headings
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- Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries a risk of sudden death. We aimed to assess whether vectorcardiographic (VCG) parameters directed toward the right heart and a measured angle of the S-wave would help differentiate ARVD/C with otherwise normal electrocardiograms from controls. Methods: Task Force 2010 definite ARVD/C criteria were met for all patients. Those who did not fulfill Task Force depolarization or repolarization criteria (-ECG) were compared with age and gender-matched control subjects. Electrocardiogram measures of a 3-dimentional spatial QRS-T angle, a right-precordial-directed orthogonal QRS-T (RPD) angle, a root mean square of the right sided depolarizing forces (RtRMS-QRS), QRS duration (QRSd) and the corrected QT interval (QTc), and a measured angle including the upslope and downslope of the S-wave (S-wave angle) were assessed. Results: Definite ARVD/C was present in 155 patients by 2010 Task Force criteria (41.7 ± 17.6 years, 65.2% male). -ECG ARVD/C patients (66 patients) were compared to 66 control patients (41.7 ± 17.6 years, 65.2% male). All parameters tested except the QRSd and QTc significantly differentiated -ECG ARVD/C from control patients (p < 0.004 to p < 0.001). The RPD angle and RtRMS-QRS best differentiated the groups. Combined, the 2 novel criteria gave 81.8% sensitivity, 90.9% specificity and odds ratio of 45.0 (95% confidence interval 15.8 to 128.2). Conclusion: ARVD/C disease process may lead to development of subtle ECG abnormalities that can be distinguishable using right-sided VCG or measured angle markers better than the spatial QRS-T angle, the QRSd or QTc, in the absence of Taskforce ECG criteria.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Arrhythmogenic right ventricular cardiomyopathy
- Cascade screening
- ECG
- Vectorcardiography
- Arrhythmogenic right ventricular cardiomyopathy; Vectorcardiography; ECG; Cascade screening
Publication and Content Type
- art (subject category)
- ref (subject category)
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