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Cardiac hypoxic res...
Cardiac hypoxic resistance and decreasing lactate during maximum apnea in elite breath hold divers
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- Kjeld, Thomas (author)
- University of Copenhagen
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- Møller, Jakob (author)
- University of Copenhagen
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- Fogh, Kristian (author)
- University of Copenhagen
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- Hansen, Egon Godthaab (author)
- University of Copenhagen
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- Arendrup, Henrik Christian (author)
- Copenhagen University Hospital
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- Isbrand, Anders Brenøe (author)
- Herlev Hospital
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Zerahn, Bo (author)
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- Højberg, Jens (author)
- Copenhagen University Hospital
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- Ostenfeld, Ellen (author)
- Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital
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- Thomsen, Henrik (author)
- University of Copenhagen
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- Gormsen, Lars Christian (author)
- Aarhus University Hospital
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- Carlsson, Marcus (author)
- Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2021-01-28
- 2021
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1
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Abstract
Subject headings
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- Breath-hold divers (BHD) enduring apnea for more than 4 min are characterized by resistance to release of reactive oxygen species, reduced sensitivity to hypoxia, and low mitochondrial oxygen consumption in their skeletal muscles similar to northern elephant seals. The muscles and myocardium of harbor seals also exhibit metabolic adaptations including increased cardiac lactate-dehydrogenase-activity, exceeding their hypoxic limit. We hypothesized that the myocardium of BHD possesses similar adaptive mechanisms. During maximum apnea 15O-H2O-PET/CT (n = 6) revealed no myocardial perfusion deficits but increased myocardial blood flow (MBF). Cardiac MRI determined blood oxygen level dependence oxygenation (n = 8) after 4 min of apnea was unaltered compared to rest, whereas cine-MRI demonstrated increased left ventricular wall thickness (LVWT). Arterial blood gases were collected after warm-up and maximum apnea in a pool. At the end of the maximum pool apnea (5 min), arterial saturation decreased to 52%, and lactate decreased 20%. Our findings contrast with previous MR studies of BHD, that reported elevated cardiac troponins and decreased myocardial perfusion after 4 min of apnea. In conclusion, we demonstrated for the first time with 15O-H2O-PET/CT and MRI in elite BHD during maximum apnea, that MBF and LVWT increases while lactate decreases, indicating anaerobic/fat-based cardiac-metabolism similar to diving mammals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Adaptation, Physiological
- Adult
- Apnea/metabolism
- Blood Gas Analysis
- Blood Pressure
- Breath Holding
- Diving
- Female
- Heart Rate
- Hemodynamics
- Humans
- Hypoxia/metabolism
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Myocardium/metabolism
- Positron Emission Tomography Computed Tomography
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Kjeld, Thomas
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Møller, Jakob
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Fogh, Kristian
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Hansen, Egon God ...
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Arendrup, Henrik ...
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Isbrand, Anders ...
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show more...
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Zerahn, Bo
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Højberg, Jens
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Ostenfeld, Ellen
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Thomsen, Henrik
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Gormsen, Lars Ch ...
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Carlsson, Marcus
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Sport and Fitnes ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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Lund University