Search: id:"swepub:oai:lup.lub.lu.se:75b9293d-200d-4e67-972c-4f78d32c275f" >
Familial risk of pl...
Familial risk of pleural mesothelioma increased drastically in certain occupations : A nationwide prospective cohort study
-
- Kharazmi, Elham (author)
- German Cancer Research Centre,National Centre of Tumor Diseases
-
- Chen, Tianhui (author)
- Zhejiang Academy of Medical Sciences
-
- Fallah, Mahdi (author)
- National Centre of Tumor Diseases,German Cancer Research Centre
-
show more...
-
- Sundquist, Kristina (author)
- Lund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups,Shimane University,Icahn School of Medicine at Mount Sinai
-
- Sundquist, Jan (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Icahn School of Medicine at Mount Sinai,Shimane University
-
- Albin, Maria (author)
- Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Arbetsorganisation och hälsa,Forskargrupper vid Lunds universitet,Environmental health and occupational health,Lund University Research Groups
-
- Weiderpass, Elisabete (author)
- Karolinska Institutet,Karolinska Institute,University of Helsinki,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research
-
- Hemminki, Kari (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English 6 s.
-
In: European Journal of Cancer. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 103, s. 1-6
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Objective: We aimed to explore the effect of occupation on familial risk of pleural mesothelioma in a nationwide cohort study design. Method: The nationwide Swedish Family-Cancer Database includes all Swedes born after 1931 and their biological parents, totalling 16.1 million individuals with about 2.3 million cancer patients. Hazards ratios (HRs) were calculated adjusting for age, sex and region of residence. Results: Having asbestos-related occupation in the absence of family history of mesothelioma increased risk of mesothelioma more than threefold (adjusted HR = 3.2, 95% confidence interval [CI]: 3.0–3.5). In those who had a history of mesothelioma in their first-degree relatives and an asbestos-related occupation, risk of mesothelioma dramatically increased compared with individuals without such occupations and family history (without chronic obstructive pulmonary disease [COPD] HR = 24, 95% CI: 15–39; with COPD 45, 95% CI: 15–141). In those who had a family history of mesothelioma and no history of an asbestos-related occupation, risk of mesothelioma did not show significant increase compared with those who had no family history of mesothelioma and no asbestos-related occupation (HR = 1.6; 95% CI: 0.7–3.8). Conclusion: First-degree relatives of patients with pleural mesothelioma had a drastic risk of developing this malignancy in case of certain occupations, which shows a gene–environment interaction is probable in risk of mesothelioma.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Familial risk
- First-degree relatives
- Mesothelioma
- Occupation
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database