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Comparison of the A...
Comparison of the ADNEX and ROMA risk prediction models for the diagnosis of ovarian cancer : a multicentre external validation in patients who underwent surgery
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- Landolfo, Chiara (author)
- Catholic University of Leuven,Policlinico Universitario Agostino Gemelli,Queen Charlotte's and Chelsea Hospital
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- Ceusters, Jolien (author)
- Catholic University of Leuven
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- Valentin, Lil (author)
- Lund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups,Skåne University Hospital
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- Froyman, Wouter (author)
- Catholic University of Leuven,University Hospitals Leuven
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- Van Gorp, Toon (author)
- Leuven Cancer Institute,University Hospitals Leuven
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- Heremans, Ruben (author)
- University Hospitals Leuven,Catholic University of Leuven
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- Baert, Thaïs (author)
- University Hospitals Leuven,Leuven Cancer Institute
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- Wouters, Roxanne (author)
- Catholic University of Leuven
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- Vankerckhoven, Ann (author)
- Catholic University of Leuven
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- Van Rompuy, Anne Sophie (author)
- University Hospitals Leuven
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- Billen, Jaak (author)
- University Hospitals Leuven
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- Moro, Francesca (author)
- Policlinico Universitario Agostino Gemelli
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- Mascilini, Floriana (author)
- Policlinico Universitario Agostino Gemelli
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- Neumann, Adam (author)
- Charles University in Prague,General University Hospital in Prague
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- Van Holsbeke, Caroline (author)
- Hospital Oost-Limburg
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- Chiappa, Valentina (author)
- Istituto Nazionale dei Tumori
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- Bourne, Tom (author)
- Queen Charlotte's and Chelsea Hospital,Catholic University of Leuven
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- Fischerova, Daniela (author)
- General University Hospital in Prague,Charles University in Prague
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- Testa, Antonia (author)
- Policlinico Universitario Agostino Gemelli
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- Coosemans, An (author)
- Catholic University of Leuven
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- Timmerman, Dirk (author)
- Catholic University of Leuven,University Hospitals Leuven
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- Van Calster, Ben (author)
- Leiden University Medical Centre,Catholic University of Leuven
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- English.
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In: British Journal of Cancer. - 0007-0920.
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Abstract
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- Background: Several diagnostic prediction models to help clinicians discriminate between benign and malignant adnexal masses are available. This study is a head-to-head comparison of the performance of the Assessment of Different NEoplasias in the adneXa (ADNEX) model with that of the Risk of Ovarian Malignancy Algorithm (ROMA). Methods: This is a retrospective study based on prospectively included consecutive women with an adnexal tumour scheduled for surgery at five oncology centres and one non-oncology centre in four countries between 2015 and 2019. The reference standard was histology. Model performance for ADNEX and ROMA was evaluated regarding discrimination, calibration, and clinical utility. Results: The primary analysis included 894 patients, of whom 434 (49%) had a malignant tumour. The area under the receiver operating characteristic curve (AUC) was 0.92 (95% CI 0.88–0.95) for ADNEX with CA125, 0.90 (0.84–0.94) for ADNEX without CA125, and 0.85 (0.80–0.89) for ROMA. ROMA, and to a lesser extent ADNEX, underestimated the risk of malignancy. Clinical utility was highest for ADNEX. ROMA had no clinical utility at decision thresholds <27%. Conclusions: ADNEX had better ability to discriminate between benign and malignant adnexal tumours and higher clinical utility than ROMA. Clinical trial registration: clinicaltrials.gov NCT01698632 and NCT02847832.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Landolfo, Chiara
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Ceusters, Jolien
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Valentin, Lil
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Froyman, Wouter
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Van Gorp, Toon
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Heremans, Ruben
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Baert, Thaïs
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Wouters, Roxanne
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Vankerckhoven, A ...
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Van Rompuy, Anne ...
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Billen, Jaak
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Moro, Francesca
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Mascilini, Flori ...
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Neumann, Adam
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Van Holsbeke, Ca ...
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Chiappa, Valenti ...
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Bourne, Tom
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Fischerova, Dani ...
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Testa, Antonia
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Coosemans, An
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Timmerman, Dirk
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Van Calster, Ben
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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British Journal ...
- By the university
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Lund University