Sökning: id:"swepub:oai:lup.lub.lu.se:9f8025b2-ea67-476e-abb4-651f3c5fcd5d" >
Patients with Lemie...
Patients with Lemierre syndrome have a high risk of new thromboembolic complications, clinical sequelae and death : an analysis of 712 cases
-
- Valerio, Luca (författare)
- Universitätsmedizin Mainz
-
- Zane, Federica (författare)
- Hospital of Sondrio
-
- Sacco, Clara (författare)
- Humanitas Research Hospital
-
visa fler...
-
Granziera, Serena (författare)
-
- Nicoletti, Tommaso (författare)
- Policlinico Universitario Agostino Gemelli
-
- Russo, Mariaconcetta (författare)
- Universitätsmedizin Mainz
-
- Corsi, Gabriele (författare)
- Fatebenefratelli Hospital
-
- Holm, Karin (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Translationell infektionsmedicin,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Translational infection medicine,Lund University Research Groups
-
- Hotz, Michel André (författare)
- University of Bern
-
- Righini, Christian (författare)
- Grenoble University Hospital
-
- Karkos, Petros D. (författare)
- Aristotle University of Thessaloniki
-
- Mahmoudpour, Seyed Hamidreza (författare)
- Universitätsmedizin Mainz
-
- Kucher, Nils (författare)
- University Hospital of Zurich
-
- Verhamme, Peter (författare)
- University Hospitals Leuven
-
- Di Nisio, Marcello (författare)
- University G.d'Annunzio of Chieti-Pescara
-
Centor, Robert M. (författare)
-
- Konstantinides, Stavros V. (författare)
- Democritus University of Thrace,Universitätsmedizin Mainz
-
- Pecci, Alessandro (författare)
- Policlinico San Matteo Pavia Fondazione
-
- Barco, Stefano (författare)
- Universitätsmedizin Mainz,University Hospital of Zurich
-
visa färre...
-
(creator_code:org_t)
- 2020-06-18
- 2021
- Engelska.
-
Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 289:3, s. 325-339
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://onlinelibrar...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Lemierre syndrome is characterized by head/neck vein thrombosis and septic embolism usually complicating an acute oropharyngeal bacterial infection in adolescents and young adults. We described the course of Lemierre syndrome in the contemporary era. Methods: In our individual-level analysis of 712 patients (2000–2017), we included cases described as Lemierre syndrome if these criteria were met: (i) primary site of bacterial infection in the head/neck; (ii) objectively confirmed local thrombotic complications or septic embolism. The study outcomes were new or recurrent venous thromboembolism or peripheral septic lesions, major bleeding, all-cause death and clinical sequelae. Results: The median age was 21 (Q1–Q3: 17–33) years, and 295 (41%) were female. At diagnosis, acute thrombosis of head/neck veins was detected in 597 (84%) patients, septic embolism in 582 (82%) and both in 468 (80%). After diagnosis and during in-hospital follow-up, new venous thromboembolism occurred in 34 (5.2%, 95% CI 3.8–7.2%) patients, new peripheral septic lesions became evident in 76 (11.7%; 9.4–14.3%). The rate of either was lower in patients who received anticoagulation (OR: 0.59; 0.36–0.94), higher in those with initial intracranial involvement (OR: 2.35; 1.45–3.80). Major bleeding occurred in 19 patients (2.9%; 1.9–4.5%), and 26 died (4.0%; 2.7–5.8%). Clinical sequelae were reported in 65 (10.4%, 8.2–13.0%) individuals, often consisting of cranial nerve palsy (n = 24) and orthopaedic limitations (n = 19). Conclusions: Patients with Lemierre syndrome were characterized by a substantial risk of new thromboembolic complications and death. This risk was higher in the presence of initial intracranial involvement. One-tenth of survivors suffered major clinical sequelae.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- anticoagulation
- Fusobacterium necrophorum
- Lemierre syndrome
- pulmonary embolism
- septic embolism
- venous thromboembolism
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Valerio, Luca
-
Zane, Federica
-
Sacco, Clara
-
Granziera, Seren ...
-
Nicoletti, Tomma ...
-
Russo, Mariaconc ...
-
visa fler...
-
Corsi, Gabriele
-
Holm, Karin
-
Hotz, Michel And ...
-
Righini, Christi ...
-
Karkos, Petros D ...
-
Mahmoudpour, Sey ...
-
Kucher, Nils
-
Verhamme, Peter
-
Di Nisio, Marcel ...
-
Centor, Robert M ...
-
Konstantinides, ...
-
Pecci, Alessandr ...
-
Barco, Stefano
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Journal of Inter ...
- Av lärosätet
-
Lunds universitet