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Antral G-cell in gastrin and gastrin-cholecystokinin knockout animals

Friis-Hansen, L (author)
Wierup, Nils (author)
Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
Rehfeld, J F (author)
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Sundler, Frank (author)
Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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 (creator_code:org_t)
2005-05-20
2005
English.
In: Cell and Tissue Research. - : Springer Science and Business Media LLC. - 1432-0878 .- 0302-766X. ; 321:1, s. 141-146
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The antral hormone gastrin is the key regulator of gastric acid secretion, mucosal growth and differentiation. Gastrin is synthesized in the endocrine G-cells in the antroduodenal mucosa. We have now examined the way in which the loss of gastrin alone or gastrin plus cholecystokinin (CCK) affects the antral G-cell. Immunohistochemistry, radioimmunoassay and quantitative real-time polymerase chain reaction techniques were employed to examine the expression of genes belonging to the G-cell secretory pathway in gastrin and gastrin-CCK knockout mice. Transmission electron microscopy was used to examine the ultrastructure of the G-cells. The number of G-cells increased but the secretory granules were few and abnormally small in the G-cells of both mouse models compared with wildtypes. Thus, gastrin is not necessary for the formation of G-cells as such but the lack of gastrin reduces the number and size of their secretory granules suggesting that gastrin is vital for the formation and/or maintenance of secretory granules in G-cells.

Subject headings

NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)

Keyword

transgenic mice
ultrastructure
G-cells
secretion
gastrin
cholecystokinin

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art (subject category)
ref (subject category)

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Friis-Hansen, L
Wierup, Nils
Rehfeld, J F
Sundler, Frank
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NATURAL SCIENCES
NATURAL SCIENCES
and Biological Scien ...
and Cell Biology
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Cell and Tissue ...
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Lund University

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