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Dynamic Changes of ...
Dynamic Changes of Reproductive Hormones in Male Minipuberty : Temporal Dissociation of Leydig and Sertoli Cell Activity
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- Busch, Alexander Siegfried (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Ljubicic, Marie Lindhardt (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Upners, Emmie N. (författare)
- University of Copenhagen,Copenhagen University Hospital
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- Fischer, Margit Bistrup (författare)
- University of Copenhagen,Copenhagen University Hospital
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- Raket, Lars Lau (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Frederiksen, Hanne (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Albrethsen, Jakob (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Johannsen, Trine Holm (författare)
- University of Copenhagen,Copenhagen University Hospital
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- Hagen, Casper P. (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Juul, Anders (författare)
- Copenhagen University Hospital,University of Copenhagen
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(creator_code:org_t)
- 2022-02-28
- 2022
- Engelska 9 s.
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 107:6, s. 1560-1568
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Context: The male hypothalamic-pituitary-gonadal (HPG) axis is transiently active during the first months of life with surging serum concentrations of reproductive hormones. This period, termed minipuberty, appears to be essential for priming testicular function. Despite the central role for male reproductive function, longitudinal data on HPG axis activation in infancy is sparse. Objective: To explore the dynamics of HPG hormone activity in healthy male infants, to assess the association of HPG axis activity and testicular volume, and to establish reference curves for serum levels of reproductive hormones. Design: Prospective, longitudinal birth cohort (the COPENHAGEN Minipuberty Study, 2016-2018, 1-year follow-up). Setting: Population-based. Patients or Other Participants: Healthy, male, term, singleton newborns were followed from birth on with repeated clinical examinations including blood sampling during a 1-year follow-up. A total of 128 boys contributed to this study, while 119 participated in the postnatal follow-up. Main Outcome Measures: Serum reproductive hormone concentrations and testicular volume. Results: Reproductive hormone concentrations showed marked dynamics during the first 6 months of age. Gonadotropins, total testosterone, and insulin-like factor 3 peaked at around 1 month of age. Inhibin B, anti-Müllerian hormone, and testicular volume peaked at around 4 to 5 months. Correlations largely recapitulated typical HPG axis pathways but also differed significantly from adult men. Conclusions: We demonstrate a temporal dissociation of Leydig and Sertoli cell activity during male minipuberty and provide reference curves for reproductive hormones.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- hypothalamic-pituitary-gonadal axis
- Leydig
- male
- minipuberty
- reproduction
- Sertoli
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Busch, Alexander ...
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Ljubicic, Marie ...
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Upners, Emmie N.
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Fischer, Margit ...
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Raket, Lars Lau
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Frederiksen, Han ...
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Albrethsen, Jako ...
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Johannsen, Trine ...
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Hagen, Casper P.
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Juul, Anders
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- MEDICIN OCH HÄLSOVETENSKAP
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