Search: id:"swepub:oai:lup.lub.lu.se:ca6e18f0-8052-489a-b7cc-7c04728ddb19" >
CD137 (4-1BB) costi...
CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation
-
- Otano, Itziar (author)
- Spanish Center for Biomedical Research Network in Oncology (CIBERONC),12 de Octubre University Hospital,Spanish National Cancer Research Center (CNIO),University of Navarra
-
- Azpilikueta, Arantza (author)
- Spanish Center for Biomedical Research Network in Oncology (CIBERONC),University of Navarra,Health Research Institute of Navarra (IDISNA)
-
- Glez-Vaz, Javier (author)
- University of Navarra,Health Research Institute of Navarra (IDISNA),Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
-
show more...
-
- Alvarez, Maite (author)
- Health Research Institute of Navarra (IDISNA),University of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
-
- Medina-Echeverz, José (author)
- Bavarian Nordic GmbH
-
- Cortés-Domínguez, Ivan (author)
- Health Research Institute of Navarra (IDISNA),University of Navarra
-
- Ortiz-de-Solorzano, Carlos (author)
- Spanish Center for Biomedical Research Network in Oncology (CIBERONC),University of Navarra,Health Research Institute of Navarra (IDISNA)
-
- Ellmark, Peter (author)
- Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH,Alligator Biosciences AB
-
- Fritzell, Sara (author)
- Alligator Biosciences AB
-
- Hernandez-Hoyos, Gabriela (author)
- Aptevo Therapeutics
-
- Nelson, Michelle Hase (author)
- Aptevo Therapeutics
-
- Ochoa, María Carmen (author)
- University Clinic of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC),Health Research Institute of Navarra (IDISNA),University of Navarra
-
- Bolaños, Elixabet (author)
- Spanish Center for Biomedical Research Network in Oncology (CIBERONC),University Clinic of Navarra,Health Research Institute of Navarra (IDISNA)
-
- Cuculescu, Doina (author)
- Spanish Center for Biomedical Research Network in Oncology (CIBERONC),Health Research Institute of Navarra (IDISNA),University of Navarra
-
- Jaúregui, Patricia (author)
- Health Research Institute of Navarra (IDISNA),Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
-
- Sanchez-Gregorio, Sandra (author)
- Health Research Institute of Navarra (IDISNA),University of Navarra,University Clinic of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
-
- Etxeberria, Iñaki (author)
- Health Research Institute of Navarra (IDISNA),University of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
-
- Rodriguez-Ruiz, María E. (author)
- Spanish Center for Biomedical Research Network in Oncology (CIBERONC),Health Research Institute of Navarra (IDISNA),University of Navarra,University Clinic of Navarra
-
- Sanmamed, Miguel F. (author)
- Spanish Center for Biomedical Research Network in Oncology (CIBERONC),University Clinic of Navarra,Health Research Institute of Navarra (IDISNA),University of Navarra
-
- Teijeira, Álvaro (author)
- University of Navarra,Health Research Institute of Navarra (IDISNA),University Clinic of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
-
- Berraondo, Pedro (author)
- Spanish Center for Biomedical Research Network in Oncology (CIBERONC),University of Navarra,Health Research Institute of Navarra (IDISNA)
-
- Melero, Ignacio (author)
- Health Research Institute of Navarra (IDISNA),University of Navarra,Spanish National Cancer Research Center (CNIO),University Clinic of Navarra,12 de Octubre University Hospital,Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
-
show less...
-
(creator_code:org_t)
- 2021-12-15
- 2021
- English.
-
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://www.nature.c...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- CD137 (4-1BB; TNFSR9) is an activation-induced surface receptor that through costimulation effects provide antigen-primed T cells with augmented survival, proliferation and effector functions as well as metabolic advantages. These immunobiological mechanisms are being utilised for cancer immunotherapy with agonist CD137-binding and crosslinking-inducing agents that elicit CD137 intracellular signaling. In this study, side-by-side comparisons show that provision of CD137 costimulation in-cis with regard to the TCR-CD3-ligating cell is superior to that provided in-trans in terms of T cell activation, proliferation, survival, cytokine secretion and mitochondrial fitness in mouse and human. Cis ligation of CD137 relative to the TCR-CD3 complex results in more intense canonical and non-canonical NF-κB signaling and provides a more robust induction of cell cycle and DNA damage repair gene expression programs. Here we report that the superiority of cis versus trans CD137-costimulation is readily observed in vivo and is relevant for understanding the immunotherapeutic effects of CAR T cells and CD137 agonistic therapies currently undergoing clinical trials, which may provide costimulation either in cis or in trans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Otano, Itziar
-
Azpilikueta, Ara ...
-
Glez-Vaz, Javier
-
Alvarez, Maite
-
Medina-Echeverz, ...
-
Cortés-Domínguez ...
-
show more...
-
Ortiz-de-Solorza ...
-
Ellmark, Peter
-
Fritzell, Sara
-
Hernandez-Hoyos, ...
-
Nelson, Michelle ...
-
Ochoa, María Car ...
-
Bolaños, Elixabe ...
-
Cuculescu, Doina
-
Jaúregui, Patric ...
-
Sanchez-Gregorio ...
-
Etxeberria, Iñak ...
-
Rodriguez-Ruiz, ...
-
Sanmamed, Miguel ...
-
Teijeira, Álvaro
-
Berraondo, Pedro
-
Melero, Ignacio
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
Nature Communica ...
- By the university
-
Lund University