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Incidence and Predi...
Incidence and Predictors of Heart Failure in Patients With Atrial Fibrillation
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- Krisai, Philipp (author)
- Centre Hospitalier Universitaire de Bordeaux,University Hospital Basel
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- Johnson, Linda S.B. (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital,Hamilton Health Sciences
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- Moschovitis, Giorgio (author)
- Hamilton Health Sciences
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- Benz, Alexander (author)
- Hamilton Health Sciences
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- Ramasundarahettige, Chinthanie (author)
- Hamilton Health Sciences
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- McIntyre, William F. (author)
- Hamilton Health Sciences
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- Wong, Jorge A. (author)
- Hamilton Health Sciences
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- Conen, David (author)
- Hamilton Health Sciences
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- Sticherling, Christian (author)
- University Hospital Basel
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- Connolly, Stuart J. (author)
- Hamilton Health Sciences
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- Healey, Jeff S. (author)
- Hamilton Health Sciences
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: CJC Open. - : Elsevier BV. - 2589-790X. ; 3:12, s. 1482-1489
- Related links:
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http://dx.doi.org/10... (free)
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http://www.cjcopen.c...
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https://doi.org/10.1...
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Abstract
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- Background: Heart failure (HF) is a frequent cause of hospitalization and death in patients with atrial fibrillation (AF). Identifying AF patients at risk of HF hospitalization could help select individuals for intensive follow-up and treatment. Methods: We pooled data from 3 randomized trials (ACTIVE-A, RE-LY, AVERROES) of AF patients, for derivation and internal validation of a risk score for first HF hospitalization. Secondary endpoints were cardiovascular death and a composite of HF hospitalizations and cardiovascular death. Results: In 23,503 patients, the mean age was 71.3 years, and 62% were male. Over a mean follow-up of 2.0 years, 875 patients (3.7%) experienced their first HF hospitalization, and 1037 patients (4.4%) died from cardiovascular causes. Incidence rates per 100 patient-years were 1.85 for HF hospitalizations, 2.15 for cardiovascular death, and 3.71 for the composite. Independent predictors for HF hospitalizations included the following: increased age, weight, heart rate and serum creatinine level, lower height and systolic blood pressure, diabetes, vascular disease, valvular disease, heart rhythm, left ventricular hypertrophy, and intraventricular conduction delay. The C-statistic (95% confidence intervals by bootstrap simulations) was 0.717 (0.705-0.732). At 2 years of follow-up, the incidence rate of the primary outcome increased across risk-score quintiles: 0.49, 0.87, 1.29, 2.44, and 4.51 per 100 patient-years, respectively. Patients in the highest quintile had an absolute risk of 6.8% for the primary endpoint at 2 years. Conclusions: In a large AF population, new-onset HF was common. A combination of characteristics can identify high-risk patients for whom strategies to prevent HF should be considered.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Krisai, Philipp
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Johnson, Linda S ...
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Moschovitis, Gio ...
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Benz, Alexander
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Ramasundarahetti ...
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McIntyre, Willia ...
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Wong, Jorge A.
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Conen, David
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Sticherling, Chr ...
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Connolly, Stuart ...
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Healey, Jeff S.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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CJC Open
- By the university
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Lund University