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Long-term outcomes ...
Long-term outcomes with haloperidol versus placebo in acutely admitted adult ICU patients with delirium
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- Mortensen, Camilla Bekker (author)
- Lund University,Lunds universitet,Hälsofrämjande komplexa interventioner,Forskargrupper vid Lunds universitet,Health-promoting Complex Interventions,Lund University Research Groups,Zealand University Hospital,CRIC - Collaboration for Research in Intensive Care
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- Andersen-Ranberg, Nina Christine (author)
- Zealand University Hospital
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- Poulsen, Lone Musaeus (author)
- Zealand University Hospital
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- Granholm, Anders (author)
- Copenhagen University Hospital
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- Rasmussen, Bodil Steen (author)
- Aalborg University,Aalborg University Hospital
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- Kjær, Maj Brit Nørregaard (author)
- Copenhagen University Hospital
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- Lange, Theis (author)
- University of Copenhagen,Copenhagen University Hospital
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- Ebdrup, Bjørn H. (author)
- University of Copenhagen
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- Collet, Marie Oxenbøll (author)
- Copenhagen University Hospital
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- Andreasen, Anne Sofie (author)
- Copenhagen University Hospital
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- Bestle, Morten Heiberg (author)
- University of Copenhagen,Copenhagen University Hospital
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- Uslu, Bülent (author)
- Zealand University Hospital
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- Pedersen, Helle Scharling (author)
- Nykøbing Falster Hospital,Zealand University Hospital
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- Nielsen, Louise Gramstrup (author)
- Odense University Hospital
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- Hästbacka, Johanna (author)
- Helsinki University Central Hospital,Tampere University Hospital
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Jensen, Troels Bek (author)
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Damgaard, Kjeld (author)
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- Sommer, Trine (author)
- Odense University Hospital
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- Morgen, Matthew (author)
- University Hospital of Wales
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Dey, Nilanjan (author)
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- Citerio, Guiseppe (author)
- University of Milano-Bicocca
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- Estrup, Stine (author)
- Copenhagen University Hospital
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- Egerod, Ingrid (author)
- Copenhagen University Hospital
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- Samuelson, Karin (author)
- Lund University,Lunds universitet,Hälsa i ett tvärvetenskapligt perspektiv,Forskargrupper vid Lunds universitet,Integrative Health Research,Lund University Research Groups
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- Perner, Anders (author)
- Copenhagen University Hospital,University of Copenhagen
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- Mathiesen, Ole (author)
- Zealand University Hospital,University of Copenhagen
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(creator_code:org_t)
- 2024
- 2024
- English 11 s.
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In: Intensive Care Medicine. - 0342-4642. ; 50:1, s. 103-113
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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Abstract
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- Purpose: We assessed long-term outcomes in acutely admitted adult patients with delirium treated in intensive care unit (ICU) with haloperidol versus placebo. Methods: We conducted pre-planned analyses of 1-year outcomes in the Agents Intervening against Delirium in the ICU (AID-ICU) trial, including mortality and health-related quality of life (HRQoL) assessed by Euroqol (EQ) 5-dimension 5-level questionnaire (EQ-5D-5L) index values and EQ visual analogue scale (EQ VAS) (deceased patients were assigned the numeric value zero). Outcomes were analysed using logistic and linear regressions with bootstrapping and G-computation, all with adjustment for the stratification variables (site and delirium motor subtype) and multiple imputations for missing HRQoL values. Results: At 1-year follow-up, we obtained vital status for 96.2% and HRQoL data for 83.3% of the 1000 randomised patients. One-year mortality was 224/501 (44.7%) in the haloperidol group versus 251/486 (51.6%) in the placebo group, with an adjusted absolute risk difference of − 6.4%-points (95% confidence interval [CI] − 12.8%-points to − 0.2%-points; P = 0.045). These results were largely consistent across the secondary analyses. For HRQoL, the adjusted mean differences were 0.04 (95% CI − 0.03 to 0.11; P = 0.091) for EQ-5D-5L-5L index values, and 3.3 (95% CI − 9.3 to 17.5; P = 0.142) for EQ VAS. Conclusions: In acutely admitted adult ICU patients with delirium, haloperidol treatment reduced mortality at 1-year follow-up, but did not statistically significantly improve HRQoL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Delirium
- Health-related quality of life
- ICU
- Long-term outcomes
- Mortality
- Treatment
Publication and Content Type
- art (subject category)
- ref (subject category)
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Mortensen, Camil ...
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Andersen-Ranberg ...
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Poulsen, Lone Mu ...
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Granholm, Anders
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Rasmussen, Bodil ...
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Kjær, Maj Brit N ...
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Lange, Theis
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Ebdrup, Bjørn H.
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Collet, Marie Ox ...
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Andreasen, Anne ...
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Bestle, Morten H ...
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Uslu, Bülent
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Pedersen, Helle ...
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Nielsen, Louise ...
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Hästbacka, Johan ...
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Jensen, Troels B ...
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Damgaard, Kjeld
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Sommer, Trine
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Morgen, Matthew
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Dey, Nilanjan
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Citerio, Guisepp ...
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Estrup, Stine
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Egerod, Ingrid
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Samuelson, Karin
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Perner, Anders
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Mathiesen, Ole
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Intensive Care M ...
- By the university
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Lund University