Search: id:"swepub:oai:lup.lub.lu.se:e4802f32-ffcc-4790-8ea2-663556f045ce" >
The transcription f...
The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer
-
Brennan, Donal (author)
-
- Ek, Sara (author)
- Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH
-
Doyle, Emma (author)
-
show more...
-
Drew, Thomas (author)
-
Foley, Michael (author)
-
Flannelly, Grainne (author)
-
O´Conner, Darren P (author)
-
Gallagher, William M (author)
-
Kilpinen, Sami (author)
-
Kallioniemi, Olli-Pekka (author)
-
- Jirström, Karin (author)
- Lund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
O'Herlihy, Colm (author)
-
- Borrebaeck, Carl (author)
- Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
-
In: European Journal of Cancer. - : Elsevier BV. - 1879-0852 .- 0959-8049. ; 45:8, s. 1510-1517
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Abstract Background: Current prognostic molecular markers for epithelial ovarian cancer (EOC) are insufficient. The aim of the current study was to investigate the role of Sox11 in EOC Methods: Using an in silico transcriptomic screen Sox11 was identified as a potential EOC biomarker. Sox11 protein expression was evaluated using immunohistochemistry (IHC) in 76 EOC cases, which were analyzed using automated algorithms to develop a quantitative scoring model. Results: Sox11 mRNA expression was up-regulated in EOC compared to normal tissues. Automated analysis of Sox11 in the EOC cohort revealed high expression of Sox11, in 40% of tumours, who had an improved recurrence free survival (RFS) (p= 0.002). Multivariate analysis confirmed Sox11 was an independent predictor of improved RFS after controlling for stage and grade. Conclusions: These data suggest that Sox11 is a new prognostic marker in EOC. Loss of SOX 11 is associated with a decreased RFS and a more aggressive phenotype.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Brennan, Donal
-
Ek, Sara
-
Doyle, Emma
-
Drew, Thomas
-
Foley, Michael
-
Flannelly, Grain ...
-
show more...
-
O´Conner, Darren ...
-
Gallagher, Willi ...
-
Kilpinen, Sami
-
Kallioniemi, Oll ...
-
Jirström, Karin
-
O'Herlihy, Colm
-
Borrebaeck, Carl
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
European Journal ...
- By the university
-
Lund University