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Replication of a No...
Replication of a Novel Parkinson's Locus in a European Ancestry Population
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- Grover, Sandeep (author)
- University of Tübingen
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- Kumar-Sreelatha, Ashwin Ashok (author)
- University of Tübingen
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Bobbili, Dheeraj R (author)
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May, Patrick (author)
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- Domenighetti, Cloé (author)
- Versailles Saint-Quentin-en-Yvelines University
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- Sugier, Pierre-Emmanuel (author)
- Versailles Saint-Quentin-en-Yvelines University
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- Schulte, Claudia (author)
- University Hospital Münster
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- Elbaz, Alexis (author)
- Versailles Saint-Quentin-en-Yvelines University
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- Krüger, Rejko (author)
- University Hospital of Tubingen
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- Gasser, Thomas (author)
- University Hospital Münster
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- Sharma, Manu (author)
- University of Tübingen
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- Puschmann, Andreas (creator_code:cre_t)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk neurogenetik,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Neurogenetics,Lund University Research Groups,Skåne University Hospital
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- Hellberg, Clara (creator_code:cre_t)
- Lund University,Lunds universitet,Klinisk neurogenetik,Forskargrupper vid Lunds universitet,Clinical Neurogenetics,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
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- 2021-03-24
- 2021
- English.
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In: Movement Disorders. - : Wiley. - 0885-3185 .- 1531-8257. ; 36:7, s. 1689-1695
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Abstract
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- BACKGROUND: A recently published East Asian genome-wide association study of Parkinson;s disease (PD) reported 2 novel risk loci, SV2C and WBSCR17.OBJECTIVES: The objective of this study were to determine whether recently reported novel SV2C and WBSCR17 loci contribute to the risk of developing PD in European and East Asian ancestry populations.METHODS: We report an association analysis of recently reported variants with PD in the COURAGE-PD cohort (9673 PD patients; 8465 controls) comprising individuals of European and East Asian ancestries. In addition, publicly available summary data (41,386 PD patients; 476,428 controls) were pooled.RESULTS: Our findings confirmed the role of the SV2C variant in PD pathogenesis (rs246814, COURAGE-PD PEuropean = 6.64 × 10-4 , pooled PD P = 1.15 × 10-11 ). The WBSCR17 rs9638616 was observed as a significant risk marker in the East Asian pooled population only (P = 1.16 × 10-8 ).CONCLUSIONS: Our comprehensive study provides an up-to-date summary of recently detected novel loci in different PD populations and confirmed the role of SV2C locus as a novel risk factor for PD irrespective of the population or ethnic group analyzed. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Asian People/genetics
- Cohort Studies
- Ethnicity
- Genetic Predisposition to Disease/genetics
- Genome-Wide Association Study
- Humans
- Parkinson Disease/genetics
- Risk Factors
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Grover, Sandeep
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Kumar-Sreelatha, ...
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Bobbili, Dheeraj ...
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May, Patrick
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Domenighetti, Cl ...
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Sugier, Pierre-E ...
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show more...
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Schulte, Claudia
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Elbaz, Alexis
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Krüger, Rejko
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Gasser, Thomas
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Sharma, Manu
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Puschmann, Andre ...
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Hellberg, Clara
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Movement Disorde ...
- By the university
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Lund University