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Respiratory chain c...
Respiratory chain complex III deficiency due to mutated BCS1L : A novel phenotype with encephalomyopathy, partially phenocopied in a Bcs1l mutant mouse model
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- Tegelberg, Saara (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Folkhälsan Research Center
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- Tomašić, Nikica (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Karolinska University Hospital
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- Kallijärvi, Jukka (författare)
- Folkhälsan Research Center
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- Purhonen, Janne (författare)
- Folkhälsan Research Center
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- Elmér, Eskil (författare)
- Lund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups
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- Lindberg, Eva (författare)
- Regional Laboratories Region Skåne
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- Nord, David Gisselsson (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine
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- Soller, Maria (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine
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- Lesko, Nicole (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Wedell, Anna (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Bruhn, Helene (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Freyer, Christoph (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Stranneheim, Henrik (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Wibom, Rolf (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Nennesmo, Inger (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Wredenberg, Anna (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Eklund, Erik A. (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Fellman, Vineta (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Folkhälsan Research Center
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(creator_code:org_t)
- 2017-04-20
- 2017
- Engelska.
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Ingår i: Orphanet Journal of Rare Diseases. - : Springer Science and Business Media LLC. - 1750-1172. ; 12:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://ojrd.biomedc...
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Abstract
Ämnesord
Stäng
- Background: Mitochondrial diseases due to defective respiratory chain complex III (CIII) are relatively uncommon. The assembly of the eleven-subunit CIII is completed by the insertion of the Rieske iron-sulfur protein, a process for which BCS1L protein is indispensable. Mutations in the BCS1L gene constitute the most common diagnosed cause of CIII deficiency, and the phenotypic spectrum arising from mutations in this gene is wide. Results: A case of CIII deficiency was investigated in depth to assess respiratory chain function and assembly, and brain, skeletal muscle and liver histology. Exome sequencing was performed to search for the causative mutation(s). The patient's platelets and muscle mitochondria showed respiration defects and defective assembly of CIII was detected in fibroblast mitochondria. The patient was compound heterozygous for two novel mutations in BCS1L, c.306A > T and c.399delA. In the cerebral cortex a specific pattern of astrogliosis and widespread loss of microglia was observed. Further analysis showed loss of Kupffer cells in the liver. These changes were not found in infants suffering from GRACILE syndrome, the most severe BCS1L-related disorder causing early postnatal mortality, but were partially corroborated in a knock-in mouse model of BCS1L deficiency. Conclusions: We describe two novel compound heterozygous mutations in BCS1L causing CIII deficiency. The pathogenicity of one of the mutations was unexpected and points to the importance of combining next generation sequencing with a biochemical approach when investigating these patients. We further show novel manifestations in brain, skeletal muscle and liver, including abnormality in specialized resident macrophages (microglia and Kupffer cells). These novel phenotypes forward our understanding of CIII deficiencies caused by BCS1L mutations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Assembly factors
- Barrel cortex
- Blue native gel electrophoresis
- Encephalopathy
- Hepatopathy
- Microglia
- Mitochondrial disorder
- Respiratory chain
- Respirometry
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Tegelberg, Saara
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Tomašić, Nikica
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Kallijärvi, Jukk ...
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Purhonen, Janne
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Elmér, Eskil
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Lindberg, Eva
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visa fler...
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Nord, David Giss ...
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Soller, Maria
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Lesko, Nicole
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Wedell, Anna
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Bruhn, Helene
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Freyer, Christop ...
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Stranneheim, Hen ...
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Wibom, Rolf
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Nennesmo, Inger
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Wredenberg, Anna
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Eklund, Erik A.
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Fellman, Vineta
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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Orphanet Journal ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet