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Pathophysiology of ...
Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk
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- Sanches, Jose Marcos (author)
- Lund University,Lunds universitet,Metabolism och leversjukdomar,Forskargrupper vid Lunds universitet,Metabolic disorders and liver disease,Lund University Research Groups
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- Zhao, Li Na (author)
- Lund University
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- Salehi, Albert (author)
- Lund University,Lunds universitet,Öcellsfysiologi,Forskargrupper vid Lunds universitet,Islet cell physiology,Lund University Research Groups
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- Wollheim, Claes B (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Diabetiska komplikationer,Translational Muscle Research,Lund University Research Groups,Diabetic Complications,University of Geneva
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- Kaldis, Philipp (author)
- Lund University,Lunds universitet,Metabolism och leversjukdomar,Forskargrupper vid Lunds universitet,Metabolic disorders and liver disease,Lund University Research Groups
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(creator_code:org_t)
- 2021-12-09
- 2023
- English.
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In: The FEBS Journal. - : Wiley. - 1742-464X .- 1742-4658. ; 290:3, s. 620-648
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Abstract
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- Diabetes is a complex and multifactorial disease that affects millions of people worldwide, reducing the quality of life significantly, and results in grave consequences for our health care system. In type 2 diabetes (T2D), the lack of β-cell compensatory mechanisms overcoming peripherally developed insulin resistance is a paramount factor leading to disturbed blood glucose levels and lipid metabolism. Impaired β-cell functions and insulin resistance have been studied extensively resulting in a good understanding of these pathways but much less is known about interorgan crosstalk, which we define as signaling between tissues by secreted factors. Besides hormones and organokines, dysregulated blood glucose and long-lasting hyperglycemia in T2D is associated with changes in metabolism with metabolites from different tissues contributing to the development of this disease. Recent data suggest that metabolites, such as lipids including free fatty acids and amino acids, play important roles in the interorgan crosstalk during the development of T2D. In general, metabolic remodeling affects physiological homeostasis and impacts the development of T2D. Hence, we highlight the importance of metabolic interorgan crosstalk in this review to gain enhanced knowledge of the pathophysiology of T2D, which may lead to new therapeutic approaches to treat this disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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