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Can sulphonylurea a...
Can sulphonylurea addition to lifestyle changes help to delay diabetes development in subjects with impaired fasting glucose? The Nepi ANtidiabetes StudY (NANSY)
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- Lindblad, Ulf, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Lindberg, Gunnar (author)
- Lund University,Lunds universitet,Samhällsmedicin,Forskargrupper vid Lunds universitet,Community Medicine,Lund University Research Groups,Department of Clinical Sciences, Clinical Research Centre, Malmö University Hospital, Lund University, Malmö, Sweden; The NEPI Foundation, Malmö, Sweden
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- Månsson, Nils-Ove (author)
- Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,Department of Clinical Sciences, Clinical Research Centre, Malmö University Hospital, Lund University, Malmö, Sweden
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- Ranstam, Jonas (author)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,The NEPI Foundation, Malmö, Sweden; Swedish National Competence Centre for Musculoskeletal Disorders, Department of Orthopædics, Lund University Hospital, Lund, Sweden
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- Tyrberg, Maria (author)
- Lund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Ophtalmology, Helsingborg Hospital, Helsingborg, Sweden; Department of Clinical Sciences, Lund University, Lund, Sweden
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- Jansson, Stefan, 1959- (author)
- Family Medicine Research Centre, Örebro University Hospital, Örebro, Sweden
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- Lindwall, K. (author)
- The NEPI Foundation, Malmö, Sweden; The NEPI Foundation, Linköping, Sweden,Skaraborg Institute, Skövde, Sweden; Skaraborg Primary Care, Skövde, Sweden
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- Svärdh, Mona (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Clinical Research Centre, Malmö University Hospital, Lund University, Malmö, Sweden; The NEPI Foundation, Malmö, Sweden
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Kindmalm, L. (author)
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- Melander, Arne (author)
- Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Samhällsmedicin,Family Medicine and Community Medicine,Lund University Research Groups,Community Medicine,Department of Clinical Sciences, Clinical Research Centre, Malmö University Hospital, Lund University, Malmö, Sweden; The NEPI Foundation, Malmö, Sweden; Community Medicine, Clinical Sciences, Malmö, Sweden
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(creator_code:org_t)
- 2010-12-27
- 2011
- English.
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In: Diabetes, Obesity and Metabolism. - Malden,USA : Wiley. - 1462-8902 .- 1463-1326. ; 13:2, s. 185-188
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Abstract
Subject headings
Close
- The Nepi ANtidiabetes StudY (NANSY) is a 5-year randomized, double-blind, placebo-controlled trial in Swedish primary care, examining whether the development of type 2 diabetes (T2D) and retinopathy (separately reported) would be delayed in 40- to 70-year-old subjects with impaired fasting glucose (IFG) who, in addition to lifestyle changes, were treated with either placebo or low-dosage sulphonylurea (SU) (1-mg glimepiride; Amaryl (R)). Of 274 subjects (163 men, 111 women), 138 were allocated to placebo (46.0% men, 56.8% women) and 136 to glimepiride (54.0% men, 43.2% women). The primary endpoint was conversion to diabetes. Average follow-up time was 3.71 years; 96 subjects converted to diabetes, 55 allocated to placebo and 41 to glimepiride (absolute difference 9.8%; p = 0.072). In conclusion, the study failed to support the notion that low-dose SU added to lifestyle changes in IFG subjects would help to delay the conversion to diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- IFG
- prevention
- primary care
- randomized trial
- sulphonylurea
- type 2
- diabetes
- type 2 diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Lindblad, Ulf, 1 ...
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Lindberg, Gunnar
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Månsson, Nils-Ov ...
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Ranstam, Jonas
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Tyrberg, Maria
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Jansson, Stefan, ...
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show more...
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Lindwall, K.
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Svärdh, Mona
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Kindmalm, L.
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Melander, Arne
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Diabetes, Obesit ...
- By the university
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Lund University
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Örebro University
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University of Gothenburg