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Integrated data ana...
Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers
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Mehine, M (author)
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Kaasinen, E (author)
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Heinonen, HR (author)
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Makinen, N (author)
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Kampjarvi, K (author)
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Sarvilinna, N (author)
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Aavikko, M (author)
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Vaharautio, A (author)
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Pasanen, A (author)
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Butzow, R (author)
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Heikinheimo, O (author)
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Sjoberg, J (author)
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Pitkanen, E (author)
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Vahteristo, P (author)
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- Aaltonen, LA (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2016-01-19
- 2016
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 113:5, s. 1315-1320
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Abstract
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- The clinical and scientific community widely regards uterine leiomyomas as a single entity, although evidence of genetic heterogeneity exists. The aim of this study was to explore transcriptional differences between leiomyomas harboring different genetic alterations, including high mobility group AT-hook 2 rearrangements, mediator complex subunit 12 mutations, biallelic inactivation of fumarate hydratase, and collagen, type IV, alpha 5-collagen, type IV, alpha 6 deletions. The evidence presented herein strongly suggests that specific driver mutations are the major determinants of expression changes in leiomyomas. Here we highlight subtype-specific expression differences in key driver pathways and emphasize the utility of stratification in leiomyoma research. Finally, we offer a set of candidate biomarkers that will facilitate the molecular classification of leiomyomas.
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- By the author/editor
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Mehine, M
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Kaasinen, E
-
Heinonen, HR
-
Makinen, N
-
Kampjarvi, K
-
Sarvilinna, N
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show more...
-
Aavikko, M
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Vaharautio, A
-
Pasanen, A
-
Butzow, R
-
Heikinheimo, O
-
Sjoberg, J
-
Pitkanen, E
-
Vahteristo, P
-
Aaltonen, LA
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show less...
- Articles in the publication
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Proceedings of t ...
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Proceedings of t ...
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Karolinska Institutet