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The EuroMyositis re...
The EuroMyositis registry: an international collaborative tool to facilitate myositis research
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Lilleker, JB (author)
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Vencovsky, J (author)
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Wang, GC (author)
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Wedderburn, LR (author)
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Diederichsen, LP (author)
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Schmidt, J (author)
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Oakley, P (author)
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Benveniste, O (author)
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Danieli, MG (author)
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Danko, K (author)
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Thuy, NTP (author)
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Vazquez-Del Mercado, M (author)
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Andersson, H (author)
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De Paepe, B (author)
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debleecker, JL (author)
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Maurer, B (author)
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McCann, LJ (author)
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Pipitone, N (author)
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McHugh, N (author)
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Betteridge, ZE (author)
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New, P (author)
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Cooper, RG (author)
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Ollier, WE (author)
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Lamb, JA (author)
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Krogh, NS (author)
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- Lundberg, IE (author)
- Karolinska Institutet
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Chinoy, H (author)
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(creator_code:org_t)
- 2017-08-30
- 2018
- English.
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In: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 77:1, s. 30-39
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https://ard.bmj.com/...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data.MethodsCross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated.ResultsOf 3067 IIM cases, 69% were female. The most common IIM subtype was dermatomyositis (DM) (31%). Smoking was more frequent in connective tissue disease overlap cases (45%, OR 1.44, 95% CI 1.09 to 1.90, p=0.012). Smoking was associated with interstitial lung disease (ILD) (OR 1.32, 95% CI 1.06 to 1.65, p=0.013), dysphagia (OR 1.43, 95% CI 1.16 to 1.77, p=0.001), malignancy ever (OR 1.78, 95% CI 1.36 to 2.33, p<0.001) and cardiac involvement (OR 2.40, 95% CI 1.60 to 3.60, p<0.001).Dysphagia occurred in 39% and cardiac involvement in 9%; either occurrence was associated with higher Health Assessment Questionnaire (HAQ) scores (adjusted OR 1.79, 95% CI 1.43 to 2.23, p<0.001). HAQ scores were also higher in inclusion body myositis cases (adjusted OR 3.85, 95% CI 2.52 to 5.90, p<0.001). Malignancy (ever) occurred in 13%, most commonly in DM (20%, OR 2.06, 95% CI 1.65 to 2.57, p<0.001).ILD occurred in 30%, most frequently in antisynthetase syndrome (71%, OR 10.7, 95% CI 8.6 to 13.4, p<0.001). Rash characteristics differed between adult-onset and juvenile-onset DM cases (‘V’ sign: 56% DM vs 16% juvenile-DM, OR 0.16, 95% CI 0.07 to 0.36, p<0.001). Glucocorticoids were used in 98% of cases, methotrexate in 71% and azathioprine in 51%.ConclusionThis large multicentre cohort demonstrates the importance of extramuscular involvement in patients with IIM, its association with smoking and its influence on disease severity. Our findings emphasise that IIM is a multisystem inflammatory disease and will help inform prognosis and clinical management of patients.
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- By the author/editor
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Lilleker, JB
-
Vencovsky, J
-
Wang, GC
-
Wedderburn, LR
-
Diederichsen, LP
-
Schmidt, J
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show more...
-
Oakley, P
-
Benveniste, O
-
Danieli, MG
-
Danko, K
-
Thuy, NTP
-
Vazquez-Del Merc ...
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Andersson, H
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De Paepe, B
-
debleecker, JL
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Maurer, B
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McCann, LJ
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Pipitone, N
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McHugh, N
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Betteridge, ZE
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New, P
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Cooper, RG
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Ollier, WE
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Lamb, JA
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Krogh, NS
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Lundberg, IE
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Chinoy, H
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show less...
- Articles in the publication
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Annals of the rh ...
- By the university
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Karolinska Institutet