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JAZF1 ameliorates a...
JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism
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Wei, Q (author)
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Zhou, BY (author)
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Yang, GY (author)
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Hu, WJ (author)
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Zhang, LL (author)
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Liu, R (author)
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Li, MY (author)
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Wang, K (author)
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Gu, HF (author)
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Guan, YF (author)
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Zhu, ZM (author)
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Zheng, HT (author)
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Peng, J (author)
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Li, L (author)
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- 2018-08-28
- 2018
- English.
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In: Cell death & disease. - : Springer Science and Business Media LLC. - 2041-4889. ; 9:9, s. 859-
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- JAZF zinc finger 1 (JAZF1) is involved in glucose and lipid metabolisms. However, its role in aging- and nutrient-related hepatic steatosis is unclear. In the current study, we demonstrated that JAZF1 expression was markedly down-regulated in obesity-associated mice and nonalcoholic fatty liver disease (NAFLD) patients. During aging, JAZF1 expression was gradually down-regulated in both C57BL/6 J and JAZF1-Tg mice. In JAZF1-Tg mice, body fat content and hepatosteatosis were protected from HFD-induced steatosis, and accompanied by decreased lipogenesis gene expression. The inhibitory effects of hepatic steatosis in JAZF1-Tg mice, however, were disappeared during aging. In hepatocytes, over-expression of JAZF1 attenuated, while knockdown of JAZF1 enhanced the expression of lipogenesis genes. The over-expressing of JAZF1 in hepatocytes displayed the increased adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and decreased sterol regulatory element-binding protein 1c (SREBP-1c) expression. The roles of JAZF1 were partially attenuated by Compound C. Mechanistically, JAZF1 suppressed SREBP-1c expression through the inhibition of transcriptional activity of liver X receptor response elements (LXREs) in the SREBP-1c promoter. Data illustrate that JAZF1 may have a crucial role in the regulation of age and nutrient-associated hepatosteatosis through an AMPK/SREBP-1c-dependent mechanism.
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- art (subject category)
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- By the author/editor
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Wei, Q
-
Zhou, BY
-
Yang, GY
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Hu, WJ
-
Zhang, LL
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Liu, R
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show more...
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Li, MY
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Wang, K
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Gu, HF
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Guan, YF
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Zhu, ZM
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Zheng, HT
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Peng, J
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Li, L
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show less...
- Articles in the publication
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Cell death & dis ...
- By the university
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Karolinska Institutet