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Risk of depression ...
Risk of depression in multiple sclerosis across disease-modifying therapies
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- Longinetti, E (författare)
- Karolinska Institutet
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- Frisell, T (författare)
- Karolinska Institutet
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- Englund, S (författare)
- Karolinska Institutet
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- Reutfors, J (författare)
- Karolinska Institutet
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- Fang, F (författare)
- Karolinska Institutet
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- Piehl, F (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-07-15
- 2022
- Engelska.
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Ingår i: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1477-0970 .- 1352-4585. ; 28:4, s. 632-641
- Relaterad länk:
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https://journals.sag...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Depression and use of antidepressants are more common among patients with multiple sclerosis (MS) compared to the general population, but the relation of psychiatric comorbidity to use of different disease-modifying therapies (DMTs) is less clear. Objective: To determine whether risk of incident depression or antidepressant use differed across DMTs, and to assess whether depression and antidepressants affected risk of DMT discontinuation and MS relapses. Methods: We prospectively followed for 8 years a register-based nationwide cohort of 3803 relapsing-remitting MS patients. Results: Patients on rituximab had a lower risk of being diagnosed with depression or initiating antidepressants compared with the reference group treated with interferons (hazard ratio (HR) = 0.72, 95% confidence interval (CI) = 0.54–0.96). Patients diagnosed with depression discontinued interferon treatment to a higher extent than patients without depression (HR = 1.51; 95% CI = 1.15–1.98), as did patients on fingolimod initiating an antidepressant compared to patients who did not initiate an antidepressant (HR = 1.47; 95% CI = 1.04–2.08). Conclusions: Our results indicate that the choice of DMT is associated with subsequent risk of depression in MS, but further studies are needed to establish whether there is a causal link. Overall, depression and use of antidepressants displayed limited associations with DMT discontinuation and MS relapse.
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