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Severe COVID-19 ind...
Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity
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Briquez, PS (author)
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Rouhani, SJ (author)
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Yu, J (author)
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Pyzer, AR (author)
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Trujillo, J (author)
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Dugan, HL (author)
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- Stamper, CT (author)
- Karolinska Institutet
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Changrob, S (author)
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Sperling, AI (author)
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Wilson, PC (author)
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Gajewski, TF (author)
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Hubbell, JA (author)
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Swartz, MA (author)
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2022
- 2022
- English.
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In: Science advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 8:40, s. eabn3777-
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https://doi.org/10.1...
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Abstract
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- Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can experience life-threatening respiratory distress, blood pressure dysregulation, and thrombosis. This is thought to be associated with an impaired activity of angiotensin-converting enzyme 2 (ACE2), which is the main entry receptor of SARS-CoV-2 and which also tightly regulates blood pressure by converting the vasoconstrictive peptide angiotensin II (AngII) to a vasopressor peptide. Here, we show that a significant proportion of hospitalized patients with COVID-19 developed autoantibodies against AngII, whose presence correlates with lower blood oxygenation, blood pressure dysregulation, and overall higher disease severity. Anti-AngII antibodies can develop upon specific immune reaction to the SARS-CoV-2 proteins Spike or receptor-binding domain (RBD), to which they can cross-bind, suggesting some epitope mimicry between AngII and Spike/RBD. These results provide important insights on how an immune reaction against SARS-CoV-2 can impair blood pressure regulation.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Briquez, PS
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Rouhani, SJ
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Yu, J
-
Pyzer, AR
-
Trujillo, J
-
Dugan, HL
-
show more...
-
Stamper, CT
-
Changrob, S
-
Sperling, AI
-
Wilson, PC
-
Gajewski, TF
-
Hubbell, JA
-
Swartz, MA
-
show less...
- Articles in the publication
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Science advances
- By the university
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Karolinska Institutet