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Genetic effects on ...
Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes
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Graham, J (author)
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Hagopian, WA (author)
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- Kockum, I (author)
- Karolinska Institutet
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- Li, LS (author)
- Karolinska Institutet
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- Sanjeevi, CB (author)
- Karolinska Institutet
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Lowe, RM (author)
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Schaefer, JB (author)
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Zarghami, M (author)
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Day, HL (author)
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- Landin-Olsson, Mona (author)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Palmer, JP (author)
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Janer-Villanueva, M (author)
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Hood, L (author)
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Sundkvist, G (author)
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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Breslow, N (author)
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- Dahlquist, Gisela (author)
- Umeå universitet,Pediatrik
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Blohme, G (author)
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(creator_code:org_t)
- American Diabetes Association, 2002
- 2002
- English.
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In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 51:5, s. 1346-1355
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Abstract
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- Age-dependent associations between type 1 diabetes risk genes HLA, INS VNTR, and CTLA-4 and autoantibodies to GAD65 (GADAs), ICA512/IA-2, insulin, and islet cells were determined by logistic regression analysis in 971 incident patients with type 1 diabetes and 702 control subjects aged 0–34 years. GADAs were associated with HLA-DQ2 in young but not in older patients (P = 0.009). Autoantibodies to insulin were negatively associated with age (P < 0.0001) but positively associated with DQ8 (P = 0.03) and with INS VNTR (P = 0.04), supporting possible immune tolerance induction. ICA512/IA-2 were negatively associated with age (P < 0.0001) and with DQ2 (P < 0.0001) but positively associated with DQ8 (P = 0.04). Males were more likely than females to be negative for GADA (P < 0.0001), autoantibodies to islet cells (P = 0.04), and all four autoantibody markers (P = 0.004). The CTLA-4 3′ end microsatellite marker was not associated with any of the autoantibodies. We conclude that age and genetic factors such as HLA-DQ and INS VNTR need to be combined with islet autoantibody markers when evaluating the risk for type 1 diabetes development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Diabetes
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To the university's database
- By the author/editor
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Graham, J
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Hagopian, WA
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Kockum, I
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Li, LS
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Sanjeevi, CB
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Lowe, RM
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show more...
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Schaefer, JB
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Zarghami, M
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Day, HL
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Landin-Olsson, M ...
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Palmer, JP
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Janer-Villanueva ...
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Hood, L
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Sundkvist, G
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Lernmark, Åke
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Breslow, N
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Dahlquist, Gisel ...
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Blohme, G
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes
- By the university
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Karolinska Institutet
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Umeå University
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Lund University