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Nanomaterial intera...
Nanomaterial interactions with biomembranes: Bridging the gap between soft matter models and biological context
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- Werner, Marco (author)
- Universitat Rovira i Virgili,Rovira i Virgili University
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- Auth, Thorsten (author)
- Forschungszentrum Jülich GmbH
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- Beales, Paul A. (author)
- University of Leeds
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- Fleury, Jean Baptiste (author)
- Universität des Saarlandes
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- Höök, Fredrik, 1966 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Kress, Holger (author)
- Universität Bayreuth,University of Bayreuth
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- Van Lehn, Reid C. (author)
- University of Wisconsin Madison
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- Müller, Marcus (author)
- Georg-August-Universität Göttingen,University of Göttingen
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- Petrov, Eugene P. (author)
- Max Planck Gesellschaft zur Förderung der Wissenschaften e.V. (MPG),Max Planck Society for the Advancement of Science (MPG)
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- Sarkisov, Lev (author)
- Ludwig-Maximilians-Universität München,Ludwig Maximilian University of Munich,University of Edinburgh
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- Sommer, Jens Uwe (author)
- Leibniz-Institut fur Polymerforschung,Leibniz Institute for Polymer Research
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- Baulin, Vladimir A. (author)
- Universitat Rovira i Virgili,Rovira i Virgili University
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(creator_code:org_t)
- American Vacuum Society, 2018
- 2018
- English.
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In: Biointerphases. - : American Vacuum Society. - 1559-4106 .- 1934-8630. ; 13:2
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Abstract
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- Synthetic polymers, nanoparticles, and carbon-based materials have great potential in applications including drug delivery, gene transfection, in vitro and in vivo imaging, and the alteration of biological function. Nature and humans use different design strategies to create nanomaterials: biological objects have emerged from billions of years of evolution and from adaptation to their environment resulting in high levels of structural complexity; in contrast, synthetic nanomaterials result from minimalistic but controlled design options limited by the authors' current understanding of the biological world. This conceptual mismatch makes it challenging to create synthetic nanomaterials that possess desired functions in biological media. In many biologically relevant applications, nanomaterials must enter the cell interior to perform their functions. An essential transport barrier is the cell-protecting plasma membrane and hence the understanding of its interaction with nanomaterials is a fundamental task in biotechnology. The authors present open questions in the field of nanomaterial interactions with biological membranes, including: how physical mechanisms and molecular forces acting at the nanoscale restrict or inspire design options; which levels of complexity to include next in computational and experimental models to describe how nanomaterials cross barriers via passive or active processes; and how the biological media and protein corona interfere with nanomaterial functionality. In this Perspective, the authors address these questions with the aim of offering guidelines for the development of next-generation nanomaterials that function in biological media.
Subject headings
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Werner, Marco
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Auth, Thorsten
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Beales, Paul A.
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Fleury, Jean Bap ...
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Höök, Fredrik, 1 ...
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Kress, Holger
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show more...
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Van Lehn, Reid C ...
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Müller, Marcus
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Petrov, Eugene P ...
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Sarkisov, Lev
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Sommer, Jens Uwe
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Baulin, Vladimir ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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and Other Physics To ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biophysics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Bioinformatics
- Articles in the publication
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Biointerphases
- By the university
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Chalmers University of Technology