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Osteogenic response...
Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro
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- de Peppo, Giuseppe Maria, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Agheli, Hossein, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Karlsson, Camilla, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Ekström, Karin, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Brisby, Helena, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics
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- Lennerås, Maria, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Gustafsson, Stefan, 1976 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Sjövall, Peter, 1961 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Johansson, Anna, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Olsson, Eva, 1960 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Lausmaa, Jukka (author)
- SP Sveriges Tekniska Forskningsinstitut AB
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- Thomsen, Peter, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Petronis, Sarunas, 1972 (author)
- SP Sveriges Tekniska Forskningsinstitut AB
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(creator_code:org_t)
- 2014-05
- 2014
- English.
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In: International journal of nanomedicine. - : Informa UK Limited. - 1176-9114 .- 1178-2013. ; 9:1, s. 2499-2515
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Abstract
Subject headings
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- Background: Patterning medical devices at the nanoscale level enables the manipulation of cell behavior and tissue regeneration, with topographic features recognized as playing a significant role in the osseointegration of implantable devices. Methods: In this study, we assessed the ability of titanium-coated hemisphere-like topographic nanostructures of different sizes (approximately 50, 100, and 200 nm) to influence the morphology, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs). Results: We found that the proliferation and osteogenic differentiation of hMSCs was influenced by the size of the underlying structures, suggesting that size variations in topographic features at the nanoscale level, independently of chemistry, can be exploited to control hMSC behavior in a size-dependent fashion. Conclusion: Our studies demonstrate that colloidal lithography, in combination with coating technologies, can be exploited to investigate the cell response to well defined nanoscale topography and to develop next-generation surfaces that guide tissue regeneration and promote implant integration.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Keyword
- cell proliferation
- osteogenic differentiation
- mineralization
- human mesenchymal stem cells
- implantable materials
- colloidal lithography
- nanotopography
- colloidal lithography; nanotopography; human mesenchymal stem cells; cell proliferation; osteogenic differentiation; mineralization; implantable materials
Publication and Content Type
- art (subject category)
- ref (subject category)
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de Peppo, Giusep ...
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Agheli, Hossein, ...
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Karlsson, Camill ...
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Ekström, Karin, ...
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Brisby, Helena, ...
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Lennerås, Maria, ...
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Gustafsson, Stef ...
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Sjövall, Peter, ...
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Johansson, Anna, ...
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Olsson, Eva, 196 ...
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Lausmaa, Jukka
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Thomsen, Peter, ...
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Petronis, Saruna ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomaterials Sci ...
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Chalmers University of Technology
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University of Gothenburg