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A metabolite from c...
A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis
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- Gu, Peng (author)
- Southern Medical University, Guangzhou, China
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- Liu, Ruofan (author)
- Southern Medical University, Guangzhou, China
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- Yang, Qin (author)
- Southern Medical University, Guangzhou, China
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- Xie, Li (author)
- Southern Medical University, Guangzhou, China
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- Wei, Rongjuan (author)
- Southern Medical University, Guangzhou, China
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- Li, Jiaxin (author)
- Southern Medical University, Guangzhou, China
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- Mei, Fengyi (author)
- Southern Medical University, Guangzhou, China
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- Chen, Tao (author)
- Southern Medical University, Guangzhou, China
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- Zeng, Zhenhua (author)
- Southern Medical University, Guangzhou, China
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- He, Yan (author)
- Southern Medical University, Guangzhou, China
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- Zhou, Hongwei (author)
- Southern Medical University, Guangzhou, China
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- Peng, Hongjuan (author)
- Southern Medical University, Guangzhou, China
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- Nandakumar, Kutty Selva, 1965- (author)
- Högskolan i Halmstad,Akademin för företagande, innovation och hållbarhet
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- Chu, Huikuan (author)
- Tongji Medical College, Wuhan, China
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- Jiang, Yong (author)
- Southern Medical University, Guangzhou, China
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- Gong, Wei (author)
- Southern Medical University, Guangzhou, China
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- Chen, Ye (author)
- Southern Medical University, Guangzhou, China
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- Schnabl, Bernd (author)
- Department of Medicine, San Diego, United States
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- Chen, Peng (author)
- Southern Medical University, Guangzhou, China
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(creator_code:org_t)
- London : Nature Publishing Group, 2023
- 2023
- English.
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In: Cellular & Molecular Immunology. - London : Nature Publishing Group. - 1672-7681 .- 2042-0226. ; 20:10, s. 1156-1170
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The gut microbiome is recognized as a key modulator of sepsis development. However, the contribution of the gut mycobiome to sepsis development is still not fully understood. Here, we demonstrated that the level of Candida albicans was markedly decreased in patients with bacterial sepsis, and the supernatant of Candida albicans culture significantly decreased the bacterial load and improved sepsis symptoms in both cecum ligation and puncture (CLP)-challenged mice and Escherichia coli-challenged pigs. Integrative metabolomics and the genetic engineering of fungi revealed that Candida albicans-derived phenylpyruvate (PPA) enhanced the bactericidal activity of macrophages and reduced organ damage during sepsis. Mechanistically, PPA directly binds to sirtuin 2 (SIRT2) and increases reactive oxygen species (ROS) production for eventual bacterial clearance. Importantly, PPA enhanced the bacterial clearance capacity of macrophages in sepsis patients and was inversely correlated with the severity of sepsis in patients. Our findings highlight the crucial contribution of commensal fungi to bacterial disease modulation and expand our understanding of the host-mycobiome interaction during sepsis development. © 2023, The Author(s), under exclusive licence to CSI and USTC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- Bacterial clearance
- Candida albicans
- Macrophage
- Phenylpyruvate
- Sepsis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gu, Peng
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Liu, Ruofan
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Yang, Qin
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Xie, Li
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Wei, Rongjuan
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Li, Jiaxin
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show more...
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Mei, Fengyi
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Chen, Tao
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Zeng, Zhenhua
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He, Yan
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Zhou, Hongwei
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Peng, Hongjuan
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Nandakumar, Kutt ...
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Chu, Huikuan
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Jiang, Yong
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Gong, Wei
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Chen, Ye
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Schnabl, Bernd
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Chen, Peng
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dermatology and ...
- Articles in the publication
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Cellular & Molec ...
- By the university
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Halmstad University