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Genetic variants and Expression of Cytochrome p450 Oxidoreductase Predict Postoperative Survival in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma
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- Huang, Ketuan (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Liao, Xiwen (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Han, Chuangye (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.
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- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Guangdong Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Zhanjiang 524001, Guangdong, Peoples R China. (creator_code:org_t)
- IVYSPRING INT PUBL, 2019
- 2019
- English.
- In: Journal of Cancer. - : IVYSPRING INT PUBL. - 1837-9664. ; 10:6, s. 1453-1465
- Journal article (peer-reviewed)
Abstract
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- Our current study investigates the prognostic values of genetic variants and mRNA expression of cytochrome p450 oxidoreductase (POR) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). A total of 19 candidate single nucleotide polymorphisms (SNPs) located in the exons of POR were genotyped using Sanger sequencing from 476 HBV-related HCC patients who underwent hepatectomy between 2003 and 2013. The mRNA expression of POR in 212 patients with HBV-related HCC was obtained from GSE14520 dataset. Survival analysis was performed to investigate the association of POR variants and mRNA expression with overall survival (OS) and recurrence-free survival (RFS). Nomograms were used to predict the prognosis of HBV-related HCC patients. Gene set enrichment analysis (GSEA) was used to investigate the mechanism of POR in HBV-related HCC prognosis. The polymorphism POR-rs1057868 was significantly associated with HBV-related HCC OS (CT/TT vs. CC, hazard ratio [HR] = 0.69, 95% confidence interval [CI] = [0.54, 0.88], P = 0.003), but not significantly associated with RFS (CT/TT vs. CC, P = 0.378). POR mRNA expression was also significantly associated with HBV-related HCC OS (high vs. low, HR = 0.61, 95% CI = [0.38, 0.97], P= 0.036), but not significantly associated with the RFS (high vs. low, P = 0.201). Two nomograms were developed to predict the HBV-related HCC OS. Furthermore, GSEA suggests that multiple gene sets were significantly enriched in liver cancer survival and recurrence, as well as POR-related target therapy in the liver. In conclusion, our study suggests that POR-rs1057868 and mRNA expression may serve as a potential postoperative prognosis biomarker in HBV-related HCC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- hepatocellular carcinoma
- cytochrome p450 oxidoreductase
- prognosis
- hepatitis B virus
- hepatectomy
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
- Huang, Ketuan
- Liao, Xiwen
- Han, Chuangye
- Wang, Xiangkun
- Yu, Tingdong
- Yang, Chengkun
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- Liu, Xiaoguang
- Yu, Long
- Chen, Zhiwei
- Qin, Wei
- Zhu, Guangzhi
- Su, Hao
- Liu, Zhengqian
- Zeng, Xianmin
- Zhou, Xin
- Lu, Sicong
- Huang, Jianlv
- Liang, Yu
- Liu, Zhengtao
- Deng, Jianlong
- Ye, Xinping
- Peng, Tao
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- MEDICAL AND HEALTH SCIENCES
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- Royal Institute of Technology
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