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Reciprocal interact...
Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer
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- Paczkowski, Marcin (författare)
- Univ Oxford, Math Inst, Oxford, England.
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- Kretzschmar, Warren W. (författare)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Med Huddinge, Ctr Hematol & Regenerat Med HERM, Stockholm, Sweden.
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- Markelc, Bostjan (författare)
- Univ Oxford, CRUK & MRC Oxford Inst Radiat Oncol, Oxford, England.
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- Liu, Stanley K. (författare)
- Univ Toronto, Sunnybrook Res Inst, Toronto, ON, Canada.;Univ Toronto, Dept Med Biophys, Toronto, ON, Canada.;Univ Toronto, Dept Radiat Oncol, Toronto, ON, Canada.
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- Kunz-Schughart, Leoni A. (författare)
- Tech Univ Dresden, Fac Med, OncoRay Natl Ctr Radiat Res Oncol, Dresden, Rossendorf, Germany.;Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dresden, Rossendorf, Germany.;Helmholtz Zentrum, Dresden, Rossendorf, Germany.;Natl Ctr Tumor Dis NCT, Partner Site, Dresden, Germany.
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- Harris, Adrian L. (författare)
- Univ Oxford, CRUK & MRC Oxford Inst Radiat Oncol, Oxford, England.;Univ Oxford, Weatherall Inst Mol Med, Oxford, England.
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- Partridge, Mike (författare)
- Univ Oxford, CRUK & MRC Oxford Inst Radiat Oncol, Oxford, England.
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- Byrne, Helen M. (författare)
- Univ Oxford, Math Inst, Oxford, England.
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- Kannan, Pavitra (författare)
- Karolinska Institutet
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Univ Oxford, Math Inst, Oxford, England Genteknologi (creator_code:org_t)
- 2021-01-04
- 2021
- Engelska.
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Ingår i: Communications Biology. - : Springer Nature. - 2399-3642. ; 4:1
- Relaterad länk:
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https://doi.org/10.1...
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- Intratumoural heterogeneity (ITH) contributes to local recurrence following radiotherapy in prostate cancer. Recent studies also show that ecological interactions between heterogeneous tumour cell populations can lead to resistance in chemotherapy. Here, we evaluated whether interactions between heterogenous populations could impact growth and response to radiotherapy in prostate cancer. Using mixed 3D cultures of parental and radioresistant populations from two prostate cancer cell lines and a predator-prey mathematical model to investigate various types of ecological interactions, we show that reciprocal interactions between heterogeneous populations enhance overall growth and reduce radiation sensitivity. The type of interaction influences the time of regrowth after radiation, and, at the population level, alters the survival and cell cycle of each population without eliminating either one. These interactions can arise from oxygen constraints and from cellular cross-talk that alter the tumour microenvironment. These findings suggest that ecological-type interactions are important in radiation response and could be targeted to reduce local recurrence. Using co-culture experiments and mathematical modelling, Paczkowski et al discover that prostate cancer spheroids comprising mixed tumour cell populations display enhanced growth and reduced radiation sensitivity due to competitive and antagonistic interactions between cell populations. This interdisciplinary approach reveals a role for ecological-type interactions in the radiation response and may be used to study other cancer types.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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