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Addition of a macro...
Addition of a macrolide to a beta-lactam in bacteremic pneumococcal pneumonia
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- Dwyer, R. (author)
- Karolinska Institutet
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- Ortqvist, A. (author)
- Karolinska Institutet
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- Aufwerber, E. (author)
- Karolinska University Hospital
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- Henriques Normark, B. (author)
- Karolinska Institutet
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- Marrie, T.J. (author)
- Walter C. Mackenzies Health Services Center
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- Mufson, M.A. (author)
- John C. Edwards School of Medicine
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- Torres, A. (author)
- Hospital Clinic de Barcelona
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- Woodhead, M.A. (author)
- Manchester Royal Infirmary
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- Ålenius, M (author)
- Karolinska University Hospital
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- Kalin, M. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2006-08-04
- 2006
- English.
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In: European Journal of Clinical Microbiology and Infectious Diseases. - : Springer Science Business Media. - 0934-9723 .- 1435-4373. ; 25:8, s. 518-521
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- In the study presented here, data collected prospectively from 340 adult patients hospitalised in five countries with bacteremic pneumococcal CAP and treated with a beta-lactam +/- a macrolide were analysed retrospectively to evaluate the efficacy of this antimicrobial combination. Univariate and multivariate analyses revealed no significant effect on case fatality rate when a macrolide/beta-lactam regimen was used as initial therapy. Results were not affected by severity of illness, or by excluding patients who died within 2 days of admission. Identified predictors of death in a multivariate regression model were age greater than 65 years (OR=2.6), two or more lung lobes affected (OR=2.2), and severity of disease as estimated using the acute physiology score (APS)greater than 8.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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