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Effect of fasting h...
Effect of fasting hyperglycemia and insulin resistance on bone turnover markers in children aged 9–11 years
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- Bilinski, Wojciech J. (författare)
- Department of Orthopaedics and Traumatology, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, Torun, Poland; Department of Orthopaedics, KoMed, Poddebickie Health Center, Poddebice, Poland
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- Szternel, Lukasz (författare)
- Department of Laboratory Medicine Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, Torun, Poland
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- Siodmiak, Joanna (författare)
- Department of Laboratory Medicine Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, Torun, Poland
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- Krintus, Magdalena (författare)
- Department of Laboratory Medicine Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, Torun, Poland
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- Paradowski, Przemyslaw T. (författare)
- Umeå universitet,Ortopedi,Department of Orthopaedics and Traumatology, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, Torun, Poland; Clinical Epidemiology Unit, Orthopaedics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
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- Domagalski, Krzysztof (författare)
- Department of Immunology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Torun, Poland
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- Sypniewska, Grazyna (författare)
- Department of Laboratory Medicine Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, Torun, Poland
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Journal of diabetes and its complications. - : Elsevier. - 1056-8727 .- 1873-460X. ; 35:10
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aim: Impaired regulation of glucose metabolism in childhood adversely affects bone health. We assessed the effect of fasting hyperglycemia and insulin resistance on bone turnover markers in prepubertal children with normal glycemia (<100 mg/dL) and fasting hyperglycemia (100-125 mg/dL).Methods: Glucose, hemoglobin A1c, IGF-I (insulin-like growth factor I), iP1NP (N-terminal propeptide of type I procollagen), CTX-1 (C-terminal telopeptide of type I collagen) and insulin were measured. Bone turnover index (BTI) and HOMA-IR (homeostasis model assessment) were calculated.Results: Bone resorption marker (CTX) levels were decreased by 26.5% in boys with hyperglycemia, though only 7% in girls. Hyperglycemia had no effect on the bone formation marker iP1NP. IGF-1, the best predictor of bone marker variance accounted for 25% of iP1NP and 5% of CTX variance. Girls presented significantly higher BTI indicating the predominance of bone formation over resorption. Insulin resistance significantly decreased CTX. In girls, HOMA-IR and IGF-1 predicted 15% of CTX variance.Conslusions: Fasting hyperglycemia and insulin resistance in children impact bone turnover suppressing bone resorption. Hyperglycemia decreased resorption, particularly in boys, while suppression of resorption by insulin resistance was more pronounced in girls. We suggest that the progression of disturbances accompanying prediabetes, may interfere with bone modelling and be deleterious to bone quality in later life.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Bone turnover markers
- Hyperglycemia
- Insulin resistance
- Osteoblasts
- Osteoclasts
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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