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Large-scale parent-...
Large-scale parent-child comparison confirms a strong paternal influence on telomere length
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- Nordfjäll, Katarina (författare)
- Umeå universitet,Patologi
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- Svenson, Ulrika (författare)
- Umeå universitet,Patologi
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- Norrback, Karl-Fredrik (författare)
- Umeå universitet,Psykiatri
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- Adolfsson, Rolf (författare)
- Umeå universitet,Psykiatri
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- Roos, Göran (författare)
- Umeå universitet,Patologi
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(creator_code:org_t)
- 2009-10-14
- 2010
- Engelska.
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Ingår i: European Journal of Human Genetics. - Basel : Karger. - 1018-4813 .- 1476-5438. ; 18:3, s. 385-389
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Telomere length is documented to have a hereditary component, and both paternal and X-linked inheritance have been proposed. We investigated blood cell telomere length in 962 individuals with an age range between 0 and 102 years. Telomere length correlations were analyzed between parent-child pairs in different age groups and between grandparent-grandchild pairs. A highly significant correlation between the father's and the child's telomere length was observed (r=0.454, P<0.001), independent of the sex of the offspring (father-son: r=0.465, P<0.001; father-daughter: r=0.484, P<0.001). For mothers, the correlations were weaker (mother-child: r=0.148, P=0.098; mother-son: r=0.080, P=0.561; mother-daughter: r=0.297, P=0.013). A positive telomere length correlation was also observed for grandparent-grandchild pairs (r=0.272, P=0.013). Our findings indicate that fathers contribute significantly stronger to the telomere length of the offspring compared with mothers (P=0.012), but we cannot exclude a maternal influence on the daughter's telomeres. Interestingly, the father-child correlations diminished with increasing age (P=0.022), suggesting that nonheritable factors have an impact on telomere length dynamics during life.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- telomere length
- heredity
- gender
- age
- Pathology
- Patologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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