Search: onr:"swepub:oai:DiVA.org:umu-87603" >
Single nucleotide p...
Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in recurrent major depressive disorder
-
Van Den Eede, Filip (author)
-
Venken, Tine (author)
-
Del-Favero, Jurgen (author)
-
show more...
-
- Norrback, Karl-Fredrik (author)
- Umeå universitet,Psykiatri
-
Souery, Daniel (author)
-
Nilsson, Lars Göran (author)
-
Van den Bossche, Bart (author)
-
Hulstijn, Wouter (author)
-
Sabbe, Bernard G. C. (author)
-
Cosyns, Paul (author)
-
Mendlewicz, Julien (author)
-
- Adolfsson, Rolf (author)
- Umeå universitet,Psykiatri
-
Van Broeckhoven, Christine (author)
-
Claes, Stephan J. (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
-
In: Psychiatry Research. - : Elsevier BV. - 0165-1781 .- 1872-7123. ; 153:1, s. 17-25
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Corticotropin-releasing factor-binding protein (CRF-BP) regulates the availability of free CRF and is a functional candidate gene for affective disorders. Previous research showed an association between polymorphisms in the CRF-BP gene and recurrent major depression (MDD) in a Swedish sample. The purpose of the current study was to re-evaluate the previous findings in an extended Swedish sample and in an independent Belgian sample of patients with recurrent MDD and in control samples. In total, 317 patients and 696 control individuals were included. Five single nucleotide polymorphisms (SNPs) and a deletion polymorphism in the CRF-BP gene were genotyped and the haplotype block structure of the gene was assessed. In the extended Swedish population, there was a trend towards an association between two SNPs and MDD. The subsequent gender analysis showed significant associations of three SNPs (CRF-BPs2 T; CRF-BPs11 T and CRF-BPs12 C) and haplotype G_T_C_T_C with MDD in Swedish males. However, these findings did not withstand correction for multiple testing and there were no significant SNP or haplotype associations in the Belgian MDD sample. In conclusion, this study does not provide confirmatory evidence for a role of the CRF-BP gene in the vulnerability for MDD in general. The association between genetic CRF-BP variants and MDD may be sexually dimorphic, but this issue requires further investigation in a larger sample.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- corticotropin-releasing factor-binding protein
- corticotropin releasing factor
- depression
- gender
- genetics
- vulnerability
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Van Den Eede, Fi ...
-
Venken, Tine
-
Del-Favero, Jurg ...
-
Norrback, Karl-F ...
-
Souery, Daniel
-
Nilsson, Lars Gö ...
-
show more...
-
Van den Bossche, ...
-
Hulstijn, Wouter
-
Sabbe, Bernard G ...
-
Cosyns, Paul
-
Mendlewicz, Juli ...
-
Adolfsson, Rolf
-
Van Broeckhoven, ...
-
Claes, Stephan J ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Psychiatry
- Articles in the publication
-
Psychiatry Resea ...
- By the university
-
Umeå University