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Wild-type MIC distr...
Wild-type MIC distributions for aminoglycoside and cyclic polypeptide antibiotics used for treatment of Mycobacterium tuberculosis infections
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- Juréen, P. (författare)
- Swedish Institute Disease Control SMI
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- Ängeby, Karin (författare)
- Karolinska Institutet,Lund University,Lunds universitet,Vård i högteknologisk miljö,Forskargrupper vid Lunds universitet,Care in high technological environments,Lund University Research Groups,Karolinska University Hospital
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- Sturegård, Erik (författare)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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- Chryssanthou, E. (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Giske, C. G. (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Werngren, J. (författare)
- Swedish Institute Disease Control SMI
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- Nordvall, M. (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Johansson, A. (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Kahlmeter, Gunnar (författare)
- Uppsala universitet,Infektionssjukdomar,Uppsala University
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- Hoffner, S. (författare)
- Swedish Institute Disease Control SMI
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- Schön, T. (författare)
- Kalmar County Hospital
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(creator_code:org_t)
- American Society for Microbiology, 2010
- 2010
- Engelska.
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Ingår i: Journal of Clinical Microbiology. - : American Society for Microbiology. - 0095-1137 .- 1098-660X. ; 48:5, s. 1853-1858
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The aminoglycosides and cyclic polypeptides are essential drugs in the treatment of multidrug-resistant tuberculosis, underscoring the need for accurate and reproducible drug susceptibility testing (DST). The epidemiological cutoff value (ECOFF) separating wild-type susceptible strains from non-wild-type strains is an important but rarely used tool for indicating susceptibility breakpoints against Mycobacterium tuberculosis. In this study, we established wild-type MIC distributions on Middlebrook 7H10 medium for amikacin, kanamycin, streptomycin, capreomycin, and viomycin using 90 consecutive clinical isolates and 21 resistant strains. Overall, the MIC variation between and within runs did not exceed +/-1 MIC dilution step, and validation of MIC values in Bactec 960 MGIT demonstrated good agreement. Tentative ECOFFs defining the wild type were established for all investigated drugs, including amikacin and viomycin, which currently lack susceptibility breakpoints for 7H10. Five out of seven amikacin- and kanamycin-resistant isolates were classified as susceptible to capreomycin according to the current critical concentration (10 mg/liter) but were non-wild type according to the ECOFF (4 mg/liter), suggesting that the critical concentration may be too high. All amikacin- and kanamycin-resistant isolates were clearly below the ECOFF for viomycin, and two of them were below the ECOFF for streptomycin, indicating that these two drugs may be considered for treatment of amikacin-resistant strains. Pharmacodynamic indices (peak serum concentration [Cmax]/MIC) were more favorable for amikacin and viomycin compared to kanamycin and capreomycin. In conclusion, our data emphasize the importance of establishing wild-type MIC distributions for improving the quality of drug susceptibility testing against Mycobacterium tuberculosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
- TECHNOLOGY
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Juréen, P.
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Ängeby, Karin
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Sturegård, Erik
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Chryssanthou, E.
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Giske, C. G.
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Werngren, J.
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visa fler...
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Nordvall, M.
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Johansson, A.
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Kahlmeter, Gunna ...
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Hoffner, S.
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Schön, T.
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- MEDICIN OCH HÄLSOVETENSKAP
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och Mikrobiologi ino ...
- Artiklar i publikationen
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Journal of Clini ...
- Av lärosätet
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Uppsala universitet
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Lunds universitet
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Karolinska Institutet
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Linköpings universitet