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Decoding Multiple B...
Decoding Multiple Biofunctions of Maca on Its Anti-allergic, Anti-inflammatory, Anti-thrombotic, and Pro-angiogenic Activities
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- Purnomo, Kartiko Arif (författare)
- Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.
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- Korinek, Michal (författare)
- Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.;Kaohsiung Med Univ, Coll Life Sci, Dept Biotechnol, Kaohsiung 80708, Taiwan.;Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Taoyuan 33302, Taiwan.;Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Res Ctr Food & Cosmet Safety, Taoyuan 33303, Taiwan.;Chang Gung Univ Sci & Technol, Coll Human Ecol, Grad Inst Hlth Ind Technol, Taoyuan 33303, Taiwan.
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- Tsai, Yi-Hong (författare)
- Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.
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- Hu, Hao-Chun (författare)
- Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.
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- Wang, Yi-Hsuan (författare)
- Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Taoyuan 33302, Taiwan.
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- Backlund, Anders, 1965- (författare)
- Uppsala universitet,Farmakognosi
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- Hwang, Tsong-Long (författare)
- Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Taoyuan 33302, Taiwan.;Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Res Ctr Food & Cosmet Safety, Taoyuan 33303, Taiwan.;Chang Gung Univ Sci & Technol, Coll Human Ecol, Grad Inst Hlth Ind Technol, Taoyuan 33303, Taiwan.;Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan 33305, Taiwan.
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- Chen, Bing-Hung (författare)
- Kaohsiung Med Univ, Coll Life Sci, Dept Biotechnol, Kaohsiung 80708, Taiwan.;Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 80708, Taiwan.
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- Wang, Shih-Wei (författare)
- Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.;MacKay Med Coll, Inst Biomed Sci, New Taipei 25245, Taiwan.;MacKay Med Coll, Dept Med, New Taipei 25245, Taiwan.
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- Wu, Chin-Chung (författare)
- Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.;MacKay Med Coll, Dept Med, New Taipei 25245, Taiwan.;Kaohsiung Med Univ, Drug Dev & Value Creat Res Ctr, Kaohsiung 80708, Taiwan.
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- Chang, Fang-Rong (författare)
- Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.;Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 80708, Taiwan.;Kaohsiung Med Univ, Drug Dev & Value Creat Res Ctr, Kaohsiung 80708, Taiwan.;Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan.
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Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.;Kaohsiung Med Univ, Coll Life Sci, Dept Biotechnol, Kaohsiung 80708, Taiwan.;Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Taoyuan 33302, Taiwan.;Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Res Ctr Food & Cosmet Safety, Taoyuan 33303, Taiwan.;Chang Gung Univ Sci & Technol, Coll Human Ecol, Grad Inst Hlth Ind Technol, Taoyuan 33303, Taiwan. (creator_code:org_t)
- 2021-09-30
- 2021
- Engelska.
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Ingår i: Journal of Agricultural and Food Chemistry. - : American Chemical Society (ACS). - 0021-8561 .- 1520-5118. ; 69:40, s. 11856-11866
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Four active partition layers and ten isolates, including (5R)- and (5S)-macapyrrolidone A (1a, 1b), and four new alkaloids, (5R)- and (5S)-macapyrrolidone B (2a, 2b) and macapyrrolins D, E (3, 4), were isolated from maca (Lepidium meyenii Walp.), an indigenous food plant from Peru. Derived from the n-hexane layer, the macamide-rich fraction exhibited pro-angiogenic activity on EPC and HUVEC cells. Anti-thrombotic activity was displayed by the polar part of maca extracts (n-butanol and water layers). Both 75% methanol aq. (midlower polar part) and n-hexane (low polar part) layers, which showed signs of fatty acid content, markedly inhibited superoxide and elastase release in an anti-inflammatory assay. The 75% methanol aq. layer showed strong anti-allergic activity, and macapyrrolin A (5) was found active based on beta-hexosaminidase release inhibition assays and a ChemGPS-NP experiment. These valuable bioactivity results suggest that maca is a food plant with good benefits for human health.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- Maca
- Lepidium meyenii
- pro-angiogenic
- anti-thrombotic
- anti-inflammatory
- anti-allergic
- ChemGPS-NP
- macamide
- macapyrrolidone
- macapyrrolin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Purnomo, Kartiko ...
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Korinek, Michal
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Tsai, Yi-Hong
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Hu, Hao-Chun
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Wang, Yi-Hsuan
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Backlund, Anders ...
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visa fler...
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Hwang, Tsong-Lon ...
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Chen, Bing-Hung
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Wang, Shih-Wei
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Wu, Chin-Chung
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Chang, Fang-Rong
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- MEDICIN OCH HÄLSOVETENSKAP
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Uppsala universitet