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Patterns of exposur...
Patterns of exposure to infectious diseases and social contacts in early life and risk of brain tumours in children and adolescents: an International Case-Control Study (CEFALO).
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Andersen, T V (author)
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Schmidt, L S (author)
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Poulsen, A H (author)
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- Feychting, M (author)
- Karolinska Institutet
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Röösli, M (author)
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Tynes, T (author)
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Aydin, D (author)
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Prochazka, M (author)
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- Lannering, Birgitta, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Klæboe, L (author)
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Eggen, T (author)
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Kuehni, C E (author)
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Schmiegelow, K (author)
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Schüz, J (author)
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(creator_code:org_t)
- 2013-05-07
- 2013
- English.
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In: British journal of cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 108, s. 2346-2353
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Abstract
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- Background:Infectious diseases and social contacts in early life have been proposed to modulate brain tumour risk during late childhood and adolescence.Methods:CEFALO is an interview-based case-control study in Denmark, Norway, Sweden and Switzerland, including children and adolescents aged 7-19 years with primary intracranial brain tumours diagnosed between 2004 and 2008 and matched population controls.Results:The study included 352 cases (participation rate: 83%) and 646 controls (71%). There was no association with various measures of social contacts: daycare attendance, number of childhours at daycare, attending baby groups, birth order or living with other children.Cases of glioma and embryonal tumours had more frequent sick days with infections in the first 6 years of life compared with controls. In 7-19 year olds with 4+ monthly sick day, the respective odds ratios were 2.93 (95% confidence interval: 1.57-5.50) and 4.21 (95% confidence interval: 1.24-14.30).Interpretation:There was little support for the hypothesis that social contacts influence childhood and adolescent brain tumour risk. The association between reported sick days due to infections and risk of glioma and embryonal tumour may reflect involvement of immune functions, recall bias or inverse causality and deserve further attention.British Journal of Cancer advance online publication 7 May 2013; doi:10.1038/bjc.2013.201 www.bjcancer.com.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- childhood brain tumour
- infectious disease
- social contact
- epidemiology
- children
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Andersen, T V
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Schmidt, L S
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Poulsen, A H
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Feychting, M
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Röösli, M
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Tynes, T
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show more...
-
Aydin, D
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Prochazka, M
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Lannering, Birgi ...
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Klæboe, L
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Eggen, T
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Kuehni, C E
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Schmiegelow, K
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Schüz, J
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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British journal ...
- By the university
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University of Gothenburg
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Karolinska Institutet