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Altered Glucose Upt...
Altered Glucose Uptake in Muscle, Visceral Adipose Tissue, and Brain Predict Whole-Body Insulin Resistance and may Contribute to the Development of Type 2 Diabetes: A Combined PET/MR Study
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- Boersma, Greta J. (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Johansson, Emil (author)
- Uppsala universitet,Radiologi
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- Pereira, Maria J, 1981- (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Heurling, Kerstin (author)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Wallenberglaboratoriet,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Wallenberg Laboratory,Radiologi,Wallenberg Centre for Molecular and Translational Medicine and the Department of Psychiatry and Neurochemistry, University of Gothenburg, Sweden
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- Skrtic, Stanko, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Lau, Joey, 1979- (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Klinisk diabetologi och metabolism
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- Katsogiannos, Petros (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Panagiotou, G. (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Lubberink, Mark (author)
- Uppsala universitet,Radiologi
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- Kullberg, Joel, 1979- (author)
- Uppsala universitet,Radiologi,Antaros Medical, Mölndal, Sweden
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- Ahlström, Håkan, 1953- (author)
- Uppsala universitet,Radiologi,Antaros Medical, Mölndal, Sweden
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- Eriksson, Jan (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
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(creator_code:org_t)
- 2018-07-12
- 2018
- English.
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In: Hormone and Metabolic Research. - : Georg Thieme Verlag KG. - 0018-5043 .- 1439-4286. ; 50:8
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Abstract
Subject headings
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- We assessed glucose uptake in different tissues in type 2 diabetes (T2D), prediabetes, and control subjects to elucidate its impact in the development of whole-body insulin resistance and T2D. Thirteen T2D, 12 prediabetes, and 10 control subjects, matched for age and BMI, underwent OGTT and abdominal subcutaneous adipose tissue (SAT) biopsies. Integrated whole-body 18F-FDG PET and MRI were performed during a hyperinsulinemic euglycemic clamp to asses glucose uptake rate (MRglu) in several tissues. MRglu in skeletal muscle, SAT, visceral adipose tissue (VAT), and liver was significantly reduced in T2D subjects and correlated positively with M-values (r = 0.884, r = 0.574, r = 0.707 and r = 0.403, respectively). Brain MRglu was significantly higher in T2D and prediabetes subjects and had a significant inverse correlation with M-values (r = -0.616). Myocardial MRglu did not differ between groups and did not correlate with the M-values. A multivariate model including skeletal muscle, brain and VAT MRglu best predicted the M-values (adjusted r2 = 0.85). In addition, SAT MRglu correlated with SAT glucose uptake ex vivo (r = 0.491). In different stages of the development of T2D, glucose uptake during hyperinsulinemia is elevated in the brain in parallel with an impairment in peripheral organs. Impaired glucose uptake in skeletal muscle and VAT together with elevated glucose uptake in brain were independently associated with whole-body insulin resistance, and these tissue-specific alterations may contribute to T2D development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- diabetes mellitus type 2
- glucose intolerance
- insulin resistance
- PET-MRI imaging
- bariatric surgery
- morbidly obese
- nervous-system
- functional mri
- fatty-acid
- metabolism
- validation
- tolerance
- transport
- lipolysis
- Endocrinology & Metabolism
- fronzo ra
- 1979
- american journal of physiology
- v237
- pe214
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Boersma, Greta J ...
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Johansson, Emil
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Pereira, Maria J ...
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Heurling, Kersti ...
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Skrtic, Stanko, ...
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Lau, Joey, 1979-
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show more...
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Katsogiannos, Pe ...
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Panagiotou, G.
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Lubberink, Mark
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Kullberg, Joel, ...
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Ahlström, Håkan, ...
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Eriksson, Jan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Hormone and Meta ...
- By the university
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University of Gothenburg
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Uppsala University