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Hallmark discoverie...
Hallmark discoveries in the biology of Wilms tumour
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- Perotti, Daniela (author)
- Istituto Nazionale dei Tumori
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- Williams, Richard D. (author)
- UCL Institute of Child Health,Imperial College London
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- Wegert, Jenny (author)
- Julius Maximilian University of Würzburg
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- Brzezinski, Jack (author)
- University of Toronto,Hospital for Sick Children, Toronto
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- Maschietto, Mariana (author)
- Boldrini Children's Hospital
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- Ciceri, Sara (author)
- Istituto Nazionale dei Tumori
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- Gisselsson, David (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Cancercellers evolution,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Pathways of cancer cell evolution,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Medical Services, Region Skåne
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- Gadd, Samantha (author)
- Ann and Robert H. Lurie Children's Hospital
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- Walz, Amy L. (author)
- Ann and Robert H. Lurie Children's Hospital
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- Furtwaengler, Rhoikos (author)
- Bern University Hospital
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- Drost, Jarno (author)
- Princess Maxima Center for Pediatric Oncology/Hematology
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- Al-Saadi, Reem (author)
- UCL Institute of Child Health,Great Ormond Street Hospital
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- Evageliou, Nicholas (author)
- The Children's Hospital of Philadelphia
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- Gooskens, Saskia L. (author)
- Princess Maxima Center for Pediatric Oncology/Hematology
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- Hong, Andrew L. (author)
- Emory University
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- Murphy, Andrew J. (author)
- St Jude Children´s Research Hospital, Memphis
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- Ortiz, Michael V. (author)
- Memorial Sloan-Kettering Cancer Center
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- O’Sullivan, Maureen J. (author)
- Trinity College Dublin
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- Mullen, Elizabeth A. (author)
- Dana-Farber Cancer Institute
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- van den Heuvel-Eibrink, Marry M. (author)
- Princess Maxima Center for Pediatric Oncology/Hematology
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- Fernandez, Conrad V. (author)
- Dalhousie University
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- Graf, Norbert (author)
- Saarland University Hospital
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- Grundy, Paul E. (author)
- University of Alberta
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- Geller, James I. (author)
- University of Cincinnati
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- Dome, Jeffrey S. (author)
- George Washington University
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- Perlman, Elizabeth J. (author)
- Ann and Robert H. Lurie Children's Hospital
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- Gessler, Manfred (author)
- Julius Maximilian University of Würzburg
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- Huff, Vicki (author)
- University of Texas
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- Pritchard-Jones, Kathy (author)
- UCL Institute of Child Health
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Nature Reviews Urology. - 1759-4812.
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The modern study of Wilms tumour was prompted nearly 50 years ago, when Alfred Knudson proposed the ‘two-hit’ model of tumour development. Since then, the efforts of researchers worldwide have substantially expanded our knowledge of Wilms tumour biology, including major advances in genetics — from cloning the first Wilms tumour gene to high-throughput studies that have revealed the genetic landscape of this tumour. These discoveries improve understanding of the embryonal origin of Wilms tumour, familial occurrences and associated syndromic conditions. Many efforts have been made to find and clinically apply prognostic biomarkers to Wilms tumour, for which outcomes are generally favourable, but treatment of some affected individuals remains challenging. Challenges are also posed by the intratumoural heterogeneity of biomarkers. Furthermore, preclinical models of Wilms tumour, from cell lines to organoid cultures, have evolved. Despite these many achievements, much still remains to be discovered: further molecular understanding of relapse in Wilms tumour and of the multiple origins of bilateral Wilms tumour are two examples of areas under active investigation. International collaboration, especially when large tumour series are required to obtain robust data, will help to answer some of the remaining unresolved questions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- By the author/editor
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Perotti, Daniela
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Williams, Richar ...
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Wegert, Jenny
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Brzezinski, Jack
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Maschietto, Mari ...
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Ciceri, Sara
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show more...
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Gisselsson, Davi ...
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Gadd, Samantha
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Walz, Amy L.
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Furtwaengler, Rh ...
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Drost, Jarno
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Al-Saadi, Reem
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Evageliou, Nicho ...
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Gooskens, Saskia ...
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Hong, Andrew L.
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Murphy, Andrew J ...
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Ortiz, Michael V ...
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O’Sullivan, Maur ...
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Mullen, Elizabet ...
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van den Heuvel-E ...
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Fernandez, Conra ...
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Graf, Norbert
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Grundy, Paul E.
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Geller, James I.
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Dome, Jeffrey S.
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Perlman, Elizabe ...
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Gessler, Manfred
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Huff, Vicki
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Pritchard-Jones, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Nature Reviews U ...
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Lund University