SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:1d27b9ca-bdd8-4170-857e-850f2eb9c0c4"
 

Search: onr:"swepub:oai:lup.lub.lu.se:1d27b9ca-bdd8-4170-857e-850f2eb9c0c4" > ALK positively regu...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

ALK positively regulates MYCN activity through repression of HBP1 expression

Claeys, Shana (author)
Ghent University Hospital,Ghent University
Denecker, Geertrui (author)
Ghent University,Ghent University Hospital
Durinck, Kaat (author)
Ghent University Hospital,Ghent University
show more...
Decaesteker, Bieke (author)
Ghent University,Ghent University Hospital
Mus, Liselot M. (author)
Ghent University Hospital,Ghent University
Loontiens, Siebe (author)
Ghent University Hospital,Ghent University
Vanhauwaert, Suzanne (author)
Ghent University,Ghent University Hospital
Althoff, Kristina (author)
University Hospital Essen
Wigerup, Caroline (author)
Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine
Bexell, Daniel (author)
Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine
Dolman, Emmy (author)
Princess Maxima Center for Pediatric Oncology/Hematology
Henrich, Kai Oliver (author)
German Cancer Research Centre
Wehrmann, Lea (author)
German Cancer Research Centre
Westerhout, Ellen M. (author)
Academic Medical Center of University of Amsterdam (AMC)
Demoulin, Jean Baptiste (author)
Catholic University of Louvain
Kumps, Candy (author)
Ghent University Hospital
Van Maerken, Tom (author)
Ghent University Hospital,Ghent University
Laureys, Genevieve (author)
Ghent University,Ghent University Hospital
Van Neste, Christophe (author)
Ghent University Hospital,Ghent University
De Wilde, Bram (author)
Ghent University,Ghent University Hospital
De Wever, Olivier (author)
Ghent University
Westermann, Frank (author)
German Cancer Research Centre
Versteeg, Rogier (author)
Academic Medical Center of University of Amsterdam (AMC)
Molenaar, Jan J. (author)
Princess Maxima Center for Pediatric Oncology/Hematology
Påhlman, Sven (author)
Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine
Schulte, Johannes H. (author)
Charité - University Medicine Berlin
De Preter, Katleen (author)
Ghent University,Ghent University Hospital
Speleman, Frank (author)
Ghent University Hospital,Ghent University
show less...
 (creator_code:org_t)
2018-12-11
2019
English.
In: Oncogene. - : Springer Science and Business Media LLC. - 0950-9232 .- 1476-5594. ; 38:15, s. 2690-2705
Related links:
http://dx.doi.org/10...
show more...
https://lup.lub.lu.s...
https://doi.org/10.1...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • ALK mutations occur in 10% of primary neuroblastomas and represent a major target for precision treatment. In combination with MYCN amplification, ALK mutations infer an ultra-high-risk phenotype resulting in very poor patient prognosis. To open up opportunities for future precision drugging, a deeper understanding of the molecular consequences of constitutive ALK signaling and its relationship to MYCN activity in this aggressive pediatric tumor entity will be essential. We show that mutant ALK downregulates the ‘HMG-box transcription factor 1’ (HBP1) through the PI3K-AKT–FOXO3a signaling axis. HBP1 inhibits both the transcriptional activating and repressing activity of MYCN, the latter being mediated through PRC2 activity. HBP1 itself is under negative control of MYCN through miR-17~92. Combined targeting of HBP1 by PI3K antagonists and MYCN signaling by BET- or HDAC-inhibitors blocks MYCN activity and significantly reduces tumor growth, suggesting a novel targeted therapy option for high-risk neuroblastoma.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Publication and Content Type

art (subject category)
ref (subject category)

Find in a library

  • Oncogene (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view