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Levosimendan: Molec...
Levosimendan: Molecular mechanisms and clinical implications Consensus of experts on the mechanisms of action of levosimendan
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Papp, Zoltan (author)
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Edes, Istvan (author)
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Fruhwald, Sonja (author)
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De Hert, Stefan G. (author)
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Salmenpera, Markku (author)
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Leppikangas, Heli (author)
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Mebazaa, Alexandre (author)
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Landoni, Giovanni (author)
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Grossini, Elena (author)
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Caimmi, Philippe (author)
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Morelli, Andrea (author)
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Guarracino, Fabio (author)
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Schwinger, Robert H. G. (author)
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Meyer, Sven (author)
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- Algotsson, Lars (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Wikstrom, Bernt Gerhard (author)
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Jorgensen, Kirsten (author)
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Filippatos, Gerasimos (author)
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Parissis, John T. (author)
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Garcia Gonzalez, Martin J. (author)
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Parkhomenko, Alexander (author)
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Yilmaz, Mehmet Birhan (author)
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Kivikko, Matti (author)
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Pollesello, Piero (author)
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Follath, Ferenc (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273. ; 159:2, s. 82-87
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Abstract
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- The molecular background of the Ca2+-sensitizing effect of levosimendan relates to its specific interaction with the Ca2+-sensor troponin C molecule in the cardiac myofilaments. Over the years, significant preclinical and clinical evidence has accumulated and revealed a variety of beneficial pleiotropic effects of levosimendan and of its long-lived metabolite, OR-1896. First of all, activation of ATP-sensitive sarcolemmal K+ channels of smooth muscle cells appears as a powerful vasodilator mechanism. Additionally, activation of ATP-sensitive K+ channels in the mitochondria potentially extends the range of cellular actions towards the modulation of mitochondrial ATP production and implicates a pharmacological mechanism for cardioprotection. Finally, it has become evident, that levosimendan possesses an isoform-selective phosphodiesterase-inhibitory effect. Interpretation of the complex mechanism of levosimendan action requires that all potential pharmacological interactions are analyzed carefully in the framework of the currently available evidence. These data indicate that the cardiovascular effects of levosimendan are exerted via more than an isolated drug-receptor interaction, and involve favorable energetic and neurohormonal changes that are unique in comparison to other types of inodilators. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Levosimendan
- Mechanism of action
- Ca2+-sensitization
- Positive
- inotropy
- Vasodilation
- Cardioprotection
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- for (subject category)
- ref (subject category)
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- By the author/editor
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Papp, Zoltan
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Edes, Istvan
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Fruhwald, Sonja
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De Hert, Stefan ...
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Salmenpera, Mark ...
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Leppikangas, Hel ...
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show more...
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Mebazaa, Alexand ...
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Landoni, Giovann ...
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Grossini, Elena
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Caimmi, Philippe
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Morelli, Andrea
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Guarracino, Fabi ...
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Schwinger, Rober ...
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Meyer, Sven
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Algotsson, Lars
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Wikstrom, Bernt ...
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Jorgensen, Kirst ...
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Filippatos, Gera ...
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Parissis, John T ...
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Garcia Gonzalez, ...
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Parkhomenko, Ale ...
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Yilmaz, Mehmet B ...
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Kivikko, Matti
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Pollesello, Pier ...
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Follath, Ferenc
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- MEDICAL AND HEALTH SCIENCES
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Lund University