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Physician-Confirmed...
Physician-Confirmed and Administrative Definitions of Stroke in UK Biobank Reflect the Same Underlying Genetic Trait
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Rannikmae, K (författare)
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Rawlik, K (författare)
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Ferguson, AC (författare)
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Avramidis, N (författare)
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Jiang, MC (författare)
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Pirastu, N (författare)
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Shen, X (författare)
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Davidson, E (författare)
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Woodfield, R (författare)
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Malik, R (författare)
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Dichgans, M (författare)
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Tenesa, A (författare)
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Sudlow, C (författare)
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- 2022-02-02
- 2022
- Engelska.
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Ingår i: Frontiers in neurology. - : Frontiers Media SA. - 1664-2295. ; 12, s. 787107-
- Relaterad länk:
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https://www.frontier...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- Stroke in UK Biobank (UKB) is ascertained via linkages to coded administrative datasets and self-report. We studied the accuracy of these codes using genetic validation.MethodsWe compiled stroke-specific and broad cerebrovascular disease (CVD) code lists (Read V2/V3, ICD-9/-10) for medical settings (hospital, death record, primary care) and self-report. Among 408,210 UKB participants, we identified all with a relevant code, creating 12 stroke definitions based on the code type and source. We performed genome-wide association studies (GWASs) for each definition, comparing summary results against the largest published stroke GWAS (MEGASTROKE), assessing genetic correlations, and replicating 32 stroke-associated loci.ResultsThe stroke case numbers identified varied widely from 3,976 (primary care stroke-specific codes) to 19,449 (all codes, all sources). All 12 UKB stroke definitions were significantly correlated with the MEGASTROKE summary GWAS results (rg.81-1) and each other (rg.4-1). However, Bonferroni-corrected confidence intervals were wide, suggesting limited precision of some results. Six previously reported stroke-associated loci were replicated using ≥1 UKB stroke definition.ConclusionsStroke case numbers in UKB depend on the code source and type used, with a 5-fold difference in the maximum case-sample size. All stroke definitions are significantly genetically correlated with the largest stroke GWAS to date.
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- art (ämneskategori)
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Rannikmae, K
-
Rawlik, K
-
Ferguson, AC
-
Avramidis, N
-
Jiang, MC
-
Pirastu, N
-
visa fler...
-
Shen, X
-
Davidson, E
-
Woodfield, R
-
Malik, R
-
Dichgans, M
-
Tenesa, A
-
Sudlow, C
-
visa färre...
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Frontiers in neu ...
- Av lärosätet
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Karolinska Institutet