1031. |
- Aaltonen, Kristina, et al.
(författare)
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Patient-derived models : Advanced tools for precision medicine in neuroblastoma
- 2023
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Ingår i: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- Neuroblastoma is a childhood cancer derived from the sympathetic nervous system. High-risk neuroblastoma patients have a poor overall survival and account for ~15% of childhood cancer deaths. There is thus a need for clinically relevant and authentic models of neuroblastoma that closely resemble the human disease to further interrogate underlying mechanisms and to develop novel therapeutic strategies. Here we review recent developments in patient-derived neuroblastoma xenograft models and in vitro cultures. These models can be used to decipher mechanisms of metastasis and treatment resistance, for drug screening, and preclinical drug testing. Patient-derived neuroblastoma models may also provide useful information about clonal evolution, phenotypic plasticity, and cell states in relation to neuroblastoma progression. We summarize current opportunities for, but also barriers to, future model development and application. Integration of patient-derived models with patient data holds promise for the development of precision medicine treatment strategies for children with high-risk neuroblastoma.
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1032. |
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1033. |
- Aaltonen, Mikko, et al.
(författare)
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Comparing Employment Trajectories before and after First Imprisonment in Four Nordic Countries
- 2017
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Ingår i: British Journal of Criminology. - : Oxford University Press (OUP). - 0007-0955 .- 1464-3529. ; 57:4, s. 828-847
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Tidskriftsartikel (refereegranskat)abstract
- Employment plays a crucial role in the re-entry process and in reducing recidivism among offenders released from prison. But at the same time, imprisonment is generally regarded as harmful to post-release employment prospects. Little is known, however, about whether or not offenders’ employment trajectories before and after imprisonment are similar across countries. As a first step towards filling this gap in research, this paper provides evidence on employment trajectories before and after imprisonment in four Nordic welfare states: Denmark, Finland, Norway and Sweden. Using data gathered from administrative records on incarcerated offenders, the analysis focuses on individuals imprisoned for the first time and who served a prison sentence less than one year in length. Results show that although employment trajectories develop in mostly similar ways before and after imprisonment across these countries, important differences exist.
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1034. |
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1035. |
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1036. |
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1037. |
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1038. |
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1039. |
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1040. |
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