| 101. |
- A, Teschendorff, et al.
(författare)
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The dynamics of DNA methylation covariation patterns in carcinogenesis
- 2014
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Ingår i: PLoS Computational Biology. - : Public Library of Science (PLoS). - 1553-734X .- 1553-7358. ; 10:7
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Tidskriftsartikel (refereegranskat)abstract
- Recently it has been observed that cancer tissue is characterised by an increased variability in DNA methylation patterns. However, how the correlative patterns in genome-wide DNA methylation change during the carcinogenic progress has not yet been explored. Here we study genome-wide inter-CpG correlations in DNA methylation, in addition to single site variability, during cervical carcinogenesis. We demonstrate how the study of changes in DNA methylation covariation patterns across normal, intra-epithelial neoplasia and invasive cancer allows the identification of CpG sites that indicate the risk of neoplastic transformation in stages prior to neoplasia. Importantly, we show that the covariation in DNA methylation at these risk CpG loci is maximal immediately prior to the onset of cancer, supporting the view that high epigenetic diversity in normal cells increases the risk of cancer. Consistent with this, we observe that invasive cancers exhibit increased covariation in DNA methylation at the risk CpG sites relative to normal tissue, but lower levels relative to pre-cancerous lesions. We further show that the identified risk CpG sites undergo preferential DNA methylation changes in relation to human papilloma virus infection and age. Results are validated in independent data including prospectively collected samples prior to neoplastic transformation. Our data are consistent with a phase transition model of carcinogenesis, in which epigenetic diversity is maximal prior to the onset of cancer. The model and algorithm proposed here may allow, in future, network biomarkers predicting the risk of neoplastic transformation to be identified.
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| 102. |
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| 103. |
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A U-turn to the Future: Sustainable Urban Mobility since 1850
- 2020
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- From local bike-sharing initiatives to overhauls of transport infrastructure, mobility is one of the most important areas in which modern cities are trying to realize a more sustainable future. Yet even as politicians and planners look ahead, there remain critical insights to be gleaned from the history of urban mobility and the unsustainable practices that still impact our everyday lives. United by their pursuit of a “usable past,” the studies in this interdisciplinary collection consider the ecological, social, and economic aspects of urban mobility, showing how historical inquiry can make both conceptual and practical contributions to the projects of sustainability and urban renewal.
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| 104. |
- A.V., Fidalgo, et al.
(författare)
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Adapting remote labs to learning scenarios : Case studies using VISIR and remotElectLab
- 2014
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Ingår i: Revista Iberoamericana de Tecnologias del Aprendizaje. - : Education Society of IEEE (Spanish Chapter). - 1932-8540. ; 9:1, s. 33-39
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Tidskriftsartikel (refereegranskat)abstract
- Remote laboratories are an emergent technological and pedagogical tool at all education levels, and their widespread use is an important part of their own improvement and evolution. This paper describes several issues encountered on laboratorial classes, on higher education courses, when using remote laboratories based on PXI systems, either using the VISIR system or an alternate in-house solution. Three main issues are presented and explained, all reported by teachers, that gave support to students' use of remote laboratories. The first issue deals with the need to allow students to select the actual place where an ammeter is to be inserted on electric circuits, even incorrectly, therefore emulating real-world difficulties. The second one deals with problems with timing when several measurements are required at short intervals, as in the discharge cycle of a capacitor. In addition, the last issue deals with the use of a multimeter in dc mode when reading ac values, a use that collides with the lab settings. All scenarios are presented and discussed, including the solution found for each case. The conclusion derived from the described work is that the remote laboratories area is an expanding field, where practical use leads to improvement and evolution of the available solutions, requiring a strict cooperation and information-sharing between all actors, i.e., developers, teachers, and students.
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| 105. |
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A Visual History of HIV/AIDS : Exploring the Face of AIDS Film Archive
- 2019
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- The Face of AIDS film archive at Karolinska Institutet, Sweden, consists of more than 700 hours of unedited and edited footage, shot over a period of more than thirty years and all over the world by filmmaker and journalist Staffan Hildebrand. The material documents the HIV/AIDS pandemic and includes scenes from conferences and rallies, and interviews with activists, physicians, people with the infection, and researchers. It represents a global historical development from the early years of the AIDS crisis to a situation in which it is possible to live a normal life with the HIV virus. This volume brings together a range of academic perspectives – from media and film studies, medical history, gender studies, history, and cultural studies – to bear on the archive, shedding light on memories, discourses, trauma, and activism.Using a medical humanities framework, the editors explore the influence of historical representations of HIV/AIDS and stigma in a world where antiretroviral treatment has fundamentally altered the conditions under which many people diagnosed with HIV live. Organized into four sections, this book begins by introducing the archive and its role, setting it in a global context. The first part looks at methodological, legal and ethical issues around archiving memories of the present which are then used to construct histories of the past; something that can be particularly controversial when dealing with a socially stigmatized epidemic such as HIV/AIDS. The second section is devoted to analyses of particular films from the archive, looking at the portrayal of people living with HIV/AIDS, the narrative of HIV as a chronic illness and the contemporary context of particular films. The third section looks at how stigma and trauma are negotiated in the material in the Face of AIDS film archive, discussing ideas about suffering and culpability. The final section contributes perspectives on and by the filmmaker as activist and auteur.This interdisciplinary collection is placed at the intersection of medical humanities, sexuality studies and film and media studies, continuing a tradition of studies on the cultural and social understandings of HIV/AIDS.
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| 106. |
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A wideband frequency selective surface reflector for 4G/X-Band/Ku-Band
- 2018
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Ingår i: Progress In Electromagnetics Research C. - : Electromagnetics Academy. - 1937-8718. ; 81, s. 151-159
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Tidskriftsartikel (refereegranskat)abstract
- A Frequency Selective Surface (FSS) reflector with wideband response for 4G/X-band/Ku-band is proposed. The wideband FSS reflector consists of cascaded dual-layer patch FSS which is etched on separate layers of FR4 substrate. The targeted frequency range is 5–16 GHz. A wide stopband of 10.4 GHz (100% percent bandwidth) is obtained with two layers in cascade. The Equivalent Circuit (EC) method is used to approximate the simulated results. An extensive parametric study is also carried out to understand the effect of various combinations of FSS layers and their disposition. A panel of final FSS is fabricated where measured and simulated results agree well.
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| 107. |
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| 108. |
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| 109. |
- Aabel, EW, et al.
(författare)
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Ventricular arrhythmias in arrhythmic mitral valve syndrome-a prospective continuous long-term cardiac monitoring study
- 2023
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Ingår i: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. - : Oxford University Press (OUP). - 1532-2092. ; 25:2, s. 506-516
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Tidskriftsartikel (refereegranskat)abstract
- AimsArrhythmic mitral valve syndrome is linked to life-threatening ventricular arrhythmias. The incidence, morphology and methods for risk stratification are not well known. This prospective study aimed to describe the incidence and the morphology of ventricular arrhythmia and propose risk stratification in patients with arrhythmic mitral valve syndrome.MethodsArrhythmic mitral valve syndrome patients were monitored for ventricular tachyarrhythmias by implantable loop recorders (ILR) and secondary preventive implantable cardioverter-defibrillators (ICD). Severe ventricular arrhythmias included ventricular fibrillation, appropriate or aborted ICD therapy, sustained ventricular tachycardia and non-sustained ventricular tachycardia with symptoms of hemodynamic instability.ResultsDuring 3.1 years of follow-up, severe ventricular arrhythmia was recorded in seven (12%) of 60 patients implanted with ILR [first event incidence rate 4% per person-year, 95% confidence interval (CI) 2–9] and in four (20%) of 20 patients with ICD (re-event incidence rate 8% per person-year, 95% CI 3–21). In the ILR group, severe ventricular arrhythmia was associated with frequent premature ventricular complexes, more non-sustained ventricular tachycardias, greater left ventricular diameter and greater posterolateral mitral annular disjunction distance (all P < 0.02).ConclusionsThe yearly incidence of ventricular arrhythmia was high in arrhythmic mitral valve syndrome patients without previous severe arrhythmias using continuous heart rhythm monitoring. The incidence was even higher in patients with secondary preventive ICD. Frequent premature ventricular complexes, non-sustained ventricular tachycardias, greater left ventricular diameter and greater posterolateral mitral annular disjunction distance were predictors of first severe arrhythmic event.
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| 110. |
- Aabel, Lise, et al.
(författare)
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A TDD Distributed MIMO Testbed Using a 1-bit Radio-Over-Fiber Fronthaul Architecture
- 2024
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Ingår i: IEEE Transactions on Microwave Theory and Techniques. - 0018-9480 .- 1557-9670. ; In Press
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Tidskriftsartikel (refereegranskat)abstract
- We present the uplink and downlink of a time-division duplex distributed multiple-input multiple-output (D-MIMO) testbed, based on a 1-bit radio-over-fiber architecture, which is low cost and scalable. The proposed architecture involves a central unit (CU) that is equipped with 1-bit digital-to-analog and analog-to-digital converters, operating at 10 GS/s. The CU is connected to multiple single-antenna remote radio heads (RRHs) via optical fibers, over which a binary radio frequency (RF) waveform is transmitted. In the uplink, a binary RF waveform is generated at the RRHs by a comparator, whose inputs are the received RF signal and a suitably designed dither signal. In the downlink, a binary RF waveform is generated at the CU via bandpass sigma-delta modulation. Our measurement results show that low error-vector magnitude (EVM) can be achieved in both the uplink and the downlink, despite 1-bit sampling at the CU. Specifically, for point-to-point over-cable transmission between a single user equipment (UE) and a CU equipped with a single RRH, we report, for a 10-MBd signal using single-carrier (SC) 16 quadratic-amplitude modulation (QAM) modulation, an EVM of 3.3% in the downlink, and of 4.5% in the uplink. We then consider a CU connected to three RRHs serving over the air two UEs, and show that, after over-the-air reciprocity calibration, a downlink zero-forcing precoder designed on the basis of uplink channel estimates at the CU achieves an EVM of 6.4% and 10.9% at UE 1 and UE 2, respectively. Finally, we investigate the ability of the proposed architecture to support orthogonal frequency-division multiplexing (OFDM) waveforms, and its robustness against both in-band and out-of-band interference.
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