| 11. |
- Gunnelin, K, et al.
(author)
-
Bond-length-dependent core hole localization observed in simple hydrocarbons
- 1999
-
In: Physical Review Letters. - 0031-9007. ; 83:7, s. 1315-1318
-
Journal article (peer-reviewed)abstract
- Soft x-ray-emission spectroscopy is applied to measure the amount of dynamic symmetry breaking in core-excited acetylene, ethylene, and ethane. Large variations are observed between the molecules and are rationalized in terms of the different C-C bond lengths: Shorter bond lengths give smaller symmetry breaking. The results also indicate that asymmetric modes are important for all the systems studied, in contradiction to previous assumptions in literature.
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
- Lernmark, Å, et al.
(author)
-
Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus
- 1995
-
In: Virchows Archiv. - 0945-6317. ; 425:6, s. 631-640
-
Journal article (peer-reviewed)abstract
- The mechanisms by which the beta cells of pancreatic islets are destroyed in insulin-dependent diabetes mellitus (IDDM) are poorly understood. In this report the pancreatic histo- and immunopathology of two children, both HLA-DR 3/4, DQ 2/8 positive and who both died from cerebral oedema within a day of clinical diagnosis of IDDM, were investigated. Patient 1, a 14-month-old girl, had a 4-week history of polydipsia and polyuria. Patient 2, a 3-year-old boy, had 2 days of illness. Both patients had a similarly severe loss of insulin cells but differed markedly as to the extent of lymphocytic islet infiltration (insulitis). Apart from insulitis, marked islet macrophage infiltration was demonstrated in both patients with the HAM-56 monoclonal antibody. Neither patient showed aberrant expression of HLA class II antigens on insulin-immunoreactive cells, but allele-specific HLA-DQ8 expression was evident on endothelial cells. Glutamic acid decarboxylase immunoreactivity was detected in both insulin- and glucagon-immunoreactive cells. It is concluded that the heterogeneity of islet pathology, especially insulitis, may reflect different dynamics and extent rather than different pathomechanisms of immune destruction of islets in IDDM.
|
|
| 16. |
|
|
| 17. |
- Bergström, Mats, et al.
(author)
-
Modulation of organ uptake of 11C-labelled L-DOPA
- 1997
-
In: Nuclear Medicine and Biology. - 0969-8051 .- 1872-9614. ; 24:1, s. 15-19
-
Journal article (peer-reviewed)abstract
- The present study was undertaken to investigate if pretreatment with pharmacological agents could change the organ uptake of 11C-labelled L-DOPA, and especially if the urinary excretion could be decreased. L-[beta-11C]DOPA was injected IV into unanesthetized Sprague-Dawley rats. After 20 min the rats were decapitated and organs taken out for radioactivity measurements. The uptake in the organs was investigated in animals only given the tracer, and in animals pretreated with drugs such as decarboxylase inhibitors carbidopa and benserazide as well as the monoamine oxidase inhibitors deprenyl, clorgyline, and the COMT inhibitor OR-486. A marked decrease in the urinary radioactivity was observed after carbidopa and benserazide administration. HPLC analysis revealed that under native conditions the major part of urinary radioactivity existed as dopamine, which was eliminated by the decarboxylase inhibitors. After pretreatment with the COMT inhibitor OR-486, the radioactivity uptake in the pancreas increased fourfold as compared to non-treated animals. HPLC analysis showed that this correlated with a marked increase in radiolabelled DOPAC. In the other organs and with the other drugs, only small effects were observed. With L-[beta-11C]fluoroDOPA as a tracer, similar results were observed although the increase in the pancreas by OR-486 had a lower magnitude. These studies suggest that it might be possible to improve the diagnostic ratio of L-[beta-11C]DOPA or L-[18F]fluoroDOPA in whole-body PET studies by pretreating the patient with decarboxylase inhibitor for reducing the urinary excretion and potentially increase the target organ uptake by COMT inhibition.
|
|
| 18. |
|
|
| 19. |
|
|
| 20. |
- Gunnelin, K, et al.
(author)
-
Bond-length-dependent core hole localization observed in simple hydrocarbons
- 1999
-
In: PHYSICAL REVIEW LETTERS. - : AMERICAN PHYSICAL SOC. - 0031-9007. ; 83:7, s. 1315-1318
-
Journal article (other academic/artistic)abstract
- Soft x-ray-emission spectroscopy is applied to measure the amount of dynamic symmetry breaking in core-excited acetylene, ethylene, and ethane. Large variations are observed between the molecules and are rationalized in terms of the different C-C bond len
|
|
