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Reduced obesity, di...
Reduced obesity, diabetes, and steatosis upon cinnamon and grape pomace are associated with changes in gut microbiota and markers of gut barrier
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Van Hul, M. (författare)
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Geurts, L. (författare)
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Plovier, H. (författare)
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visa fler...
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Druart, C. (författare)
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Everard, A. (författare)
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- Ståhlman, Marcus, 1975 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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Rhimi, M. (författare)
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Chira, K. (författare)
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Teissedre, P. L. (författare)
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Delzenne, N. M. (författare)
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Maguin, E. (författare)
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Guilbot, A. (författare)
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Brochot, A. (författare)
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Gerard, P. (författare)
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- Bäckhed, Fredrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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Cani, P. D. (författare)
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(creator_code:org_t)
- American Physiological Society, 2018
- 2018
- Engelska.
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Ingår i: American Journal of Physiology-Endocrinology and Metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 314:4
- Relaterad länk:
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https://journals.phy...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Increasing evidence suggests that polyphenols have a significant potential in the prevention and treatment of risk factors associated with metabolic syndrome. The objective of this study was to assess the metabolic outcomes of two polyphenol-containing extracts from cinnamon bark (CBE) and grape pomace (GPE) on C57BL/6J mice fed a high-fat diet (HFD) for 8 wk. Both CBE and GPK were able to decrease fat mass gain and adipose tissue inflammation in mice fed a HFD without reducing food intake. This was associated with reduced liver steatosis and lower plasma nonesterified fatty acid levels. We also observed a beneficial effect on glucose homeostasis, as evidenced by an improved glucose tolerance and a lower insulin resistance index. These ameliorations of the overall metabolic profile were associated with a significant impact on the microbial composition, which was more profound for the GPE than for the CBE. At the genus level. Peptococcus were decreased in the CBE group. In the GPE-treated group, several key genera that have been previously found to be linked with HFD, metabolic effects, and gut banter integrity were affected: we observed a decrease of Desulfovibrio, Lactococcus, whereas Allobaculum and Roseburia were increased. In addition, the expression of several antimicrobial peptides and tight junction proteins was increased in response to both CBK and GPH supplementation, indicating an improvement of the gut barrier function. Collectively, these data suggest that CBE and GPE can ameliorate the overall metabolic profile of mice on a high-fat diet, partly by acting on the gut microbiota.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- high-fat-diet
- induced insulin-resistance
- high-fructose diet
- metabolic
- syndrome
- in-vivo
- antimicrobial properties
- akkermansia-muciniphila
- intestinal microbiota
- ulcerative-colitis
- phenolic-compounds
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Van Hul, M.
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Geurts, L.
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Plovier, H.
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Druart, C.
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Everard, A.
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Ståhlman, Marcus ...
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visa fler...
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Rhimi, M.
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Chira, K.
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Teissedre, P. L.
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Delzenne, N. M.
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Maguin, E.
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Guilbot, A.
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Brochot, A.
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Gerard, P.
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Bäckhed, Fredrik ...
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Cani, P. D.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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American Journal ...
- Av lärosätet
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Göteborgs universitet