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Sökning: WFRF:(Filippov A) > (2005-2009)

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11.
  • Filippov, Andrey, et al. (författare)
  • Diffusion and aggregation of Alzheimer's A beta(1-40) peptide in aqueous trifluoroethanol solutions as studied by pulsed field gradient NMR
  • 2005
  • Ingår i: APPLIED MAGNETIC RESONANCE. - 0937-9347. ; 29:3, s. 439-49
  • Tidskriftsartikel (refereegranskat)abstract
    • Pulsed field gradient nuclear magnetic resonance technique was applied to measure the self-diffusion coefficient of A beta(1-40) peptide in trifluoroethanol (TFE) and mixed solvent TFE-water (D2O) buffer (pD 7.8) at 293 K. The data were analyzed on the basis of the Stokes model and the hard-sphere approach was used to estimate self-diffusion coefficients. It was found that the extent of the A beta(1-40) aggregation in TFE solutions depends on the concentration of the peptide and the sample preparation protocol. After soft mixing, i.e., without any additional mechanical pretreatment of the peptide, the peptide is present in the monomeric form in TFE solutions. However, the additional water-bath sonication of the sample during the dissolution of A beta(1-40) in TFE enforces oligomerization of the peptide with the size of aggregates ranging from tetra- to hexamers. An increase of D2O in the mixed TFE-D2O solvent of up to 75% leads to the aggregation of the larger part of the peptide. However, the components of self-diffusion coefficients related to low-mass A beta(1-40). oligomers (dimers and trimers) were not observed in the diffusion decay curves. The most probable explanation is that dimers and trimers are not the principal intermediate species in the aggregation of A beta(1-40) peptide.
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12.
  • Filippov, Sergey K, et al. (författare)
  • Aggregation of dextran hydrophobically modified by sterically-hindered phenols in aqueous solutions : Aggregates vs. single molecules
  • 2008
  • Ingår i: European Polymer Journal. - : Elsevier BV. - 0014-3057 .- 1873-1945. ; 44:10, s. 3361-3369
  • Tidskriftsartikel (refereegranskat)abstract
    • The hydrodynamic properties of dextrans hydrophobically modified by sterically-hindered phenols in aq. soln. were characterized by a combination of Cryogenic Transmission Electron Microscopy (Cryo-TEM), fluorescent spectroscopy, and Dynamic Light Scattering (DLS). All solns. investigated contained aggregates the structure, shape, and crit. aggregation concn. of which are influenced by the amt. of the inserted phenol groups in the polymer matrix. We found that increasing of temp. enhances aggregation. It was established that the crit. aggregation concn. could be well approximated by a logarithmic function of the substitution degree of the glycoside units. The results suggest that the proportion of aggregates is nevertheless negligible in comparison with the proportion of single mols.
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