SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Hinney Anke)
 

Search: WFRF:(Hinney Anke) > (2020-2022) > Common Genetic Vari...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Common Genetic Variation and Age of Onset of Anorexia Nervosa

Watson, Hunna J. (author)
Thornton, Laura M. (author)
Yilmaz, Zeynep (author)
show more...
Baker, Jessica H. (author)
Coleman, Jonathan R. I. (author)
Adan, Roger A. H. (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
Alfredsson, Lars (author)
Karolinska Institutet
Andreassen, Ole A. (author)
Ask, Helga (author)
Berrettini, Wade H. (author)
Boehnke, Michael (author)
Boehm, Ilka (author)
Boni, Claudette (author)
Buehren, Katharina (author)
Bulant, Josef (author)
Burghardt, Roland (author)
Chang, Xiao (author)
Cichon, Sven (author)
Cone, Roger D. (author)
Courtet, Philippe (author)
Crow, Scott (author)
Crowley, James J. (author)
Danner, Unna N. (author)
de Zwaan, Martina (author)
Dedoussis, George (author)
DeSocio, Janiece E. (author)
Dick, Danielle M. (author)
Dikeos, Dimitris (author)
Dina, Christian (author)
Djurovic, Srdjan (author)
Dmitrzak-Weglarz, Monika (author)
Docampo-Martinez, Elisa (author)
Duriez, Philibert (author)
Egberts, Karin (author)
Ehrlich, Stefan (author)
Eriksson, Johan G. (author)
Escaramis, Georgia (author)
Esko, Tonu (author)
Estivill, Xavier (author)
Farmer, Anne (author)
Fernandez-Aranda, Fernando (author)
Fichter, Manfred M. (author)
Foecker, Manuel (author)
Foretova, Lenka (author)
Forstner, Andreas J. (author)
Frei, Oleksandr (author)
Gallinger, Steven (author)
Giegling, Ina (author)
Giuranna, Johanna (author)
Gonidakis, Fragiskos (author)
Gorwood, Philip (author)
Gratacos, Monica (author)
Guillaume, Sebastien (author)
Guo, Yiran (author)
Hakonarson, Hakon (author)
Hauser, Joanna (author)
Havdahl, Alexandra (author)
Hebebrand, Johannes (author)
Helder, Sietske G. (author)
Herms, Stefan (author)
Herpertz-Dahlmann, Beate (author)
Herzog, Wolfgang (author)
Hinney, Anke (author)
Huebel, Christopher (author)
Hudson, James I. (author)
Imgart, Hartmut (author)
Jamain, Stephanie (author)
Janout, Vladimir (author)
Jimenez-Murcia, Susana (author)
Jones, Ian R. (author)
Julia, Antonio (author)
Kalsi, Gursharan (author)
Kaminska, Deborah (author)
Kaprio, Jaakko (author)
Karhunen, Leila (author)
Kas, Martien J. H. (author)
Keel, Pamela K. (author)
Kennedy, James L. (author)
Keski-Rahkonen, Anna (author)
Kiezebrink, Kirsty (author)
Klareskog, Lars (author)
Karolinska Institutet
Klump, Kelly L. (author)
Knudsen, Gun Peggy S. (author)
La Via, Maria C. (author)
Le Hellard, Stephanie (author)
Leboyer, Marion (author)
Li, Dong (author)
Lilenfeld, Lisa (author)
Karolinska Institutet
Lin, Bochao (author)
Lissowska, Jolanta (author)
Luykx, Jurjen (author)
Magistretti, Pierre (author)
Maj, Mario (author)
Karolinska Institutet
Marsal, Sara (author)
Marshall, Christian R. (author)
Mattingsdal, Morten (author)
Meulenbelt, Ingrid (author)
Micali, Nadia (author)
Mitchell, Karen S. (author)
Monteleone, Alessio Maria (author)
Monteleone, Palmiero (author)
Myers, Richard (author)
Navratilova, Marie (author)
Ntalla, Ionna (author)
O'Toole, Julie K. (author)
Ophoff, Roel A. (author)
Padyukov, Leonid (author)
Pantel, Jacques (author)
Papezova, Hana (author)
Pinto, Dalila (author)
Raevuori, Anu (author)
Ramoz, Nicolas (author)
Reichborn-Kjennerud, Ted (author)
Ricca, Valdo (author)
Ripatti, Samuli (author)
Ripke, Stephan (author)
Ritschel, Franziska (author)
Roberts, Marion (author)
Rotondo, Alessandro (author)
Rujescu, Dan (author)
Rybakowski, Filip (author)
Scherag, Andre (author)
Scherer, Stephen W. (author)
Schmidt, Ulrike (author)
Scott, Laura J. (author)
Seitz, Jochen (author)
Silen, Yasmina (author)
Slachtova, Lenka (author)
Slagboom, P. Eline (author)
Slof-Op 't Landt, Margarita C. T. (author)
Slopien, Agnieszka (author)
Sorbi, Sandro (author)
Swiatkowska, Beata (author)
Tortorella, Alfonso (author)
Tozzi, Federica (author)
Treasure, Janet (author)
Tsitsika, Artemis (author)
Tyszkiewicz-Nwafor, Marta (author)
Tziouvas, Konstantinos (author)
van Elburg, Annemarie A. (author)
van Furth, Eric F. (author)
Walton, Esther (author)
Widen, Elisabeth (author)
Zerwas, Stephanie (author)
Zipfel, Stephan (author)
Bergen, Andrew W. (author)
Boden, Joseph M. (author)
Brandt, Harry (author)
Crawford, Steven (author)
Halmi, Katherine A. (author)
Horwood, L. John (author)
Johnson, Craig (author)
Kaplan, Allan S. (author)
Kaye, Walter H. (author)
Mitchell, James E. (author)
Olsen, Catherine M. (author)
Pearson, John F. (author)
Pedersen, Nancy L. (author)
Karolinska Institutet
Strober, Michael (author)
Werge, Thomas (author)
Whiteman, David C. (author)
Woodside, D. Blake (author)
Gordon, Scott (author)
Maguire, Sarah (author)
Larsen, Janne T. (author)
Parker, Richard (author)
Petersen, Liselotte (author)
Jordan, Jennifer (author)
Kennedy, Martin (author)
Wade, Tracey D. (author)
Birgegard, Andreas (author)
Karolinska Institutet
Lichtenstein, Paul (author)
Landén, Mikael, 1966 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
Martin, Nicholas G. (author)
Mortensen, Preben Bo (author)
Breen, Gerome (author)
Bulik, Cynthia M. (author)
show less...
 (creator_code:org_t)
Elsevier BV, 2022
2022
English.
In: BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE. - : Elsevier BV. - 2667-1743. ; 2:4, s. 368-378
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • BACKGROUND: Genetics and biology may influence the age of onset of anorexia nervosa (AN). The aims of this study were to determine whether common genetic variation contributes to age of onset of AN and to investigate the genetic associations between age of onset of AN and age at menarche.METHODS: A secondary analysis of the Psychiatric Genomics Consortium genome-wide association study (GWAS) of AN was performed, which included 9335 cases and 31,981 screened controls, all from European ancestries. We conducted GWASs of age of onset, early-onset AN (,13 years), and typical-onset AN, and genetic correlation, genetic risk score, and Mendelian randomization analyses.RESULTS: Two loci were genome-wide significant in the typical-onset AN GWAS. Heritability estimates (single nucleotide polymorphism-h2) were 0.01-0.04 for age of onset, 0.16-0.25 for early-onset AN, and 0.17-0.25 for typical-onset AN. Early-and typical-onset AN showed distinct genetic correlation patterns with putative risk factors for AN. Specifically, early-onset AN was significantly genetically correlated with younger age at menarche, and typical-onset AN was significantly negatively genetically correlated with anthropometric traits. Genetic risk scores for age of onset and early-onset AN estimated from independent GWASs significantly predicted age of onset. Mendelian randomization analysis suggested a causal link between younger age at menarche and early -onset AN.CONCLUSIONS: Our results provide evidence consistent with a common variant genetic basis for age of onset and implicate biological pathways regulating menarche and reproduction.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Find more in SwePub

By the author/editor
Watson, Hunna J.
Thornton, Laura ...
Yilmaz, Zeynep
Baker, Jessica H ...
Coleman, Jonatha ...
Adan, Roger A. H ...
show more...
Alfredsson, Lars
Andreassen, Ole ...
Ask, Helga
Berrettini, Wade ...
Boehnke, Michael
Boehm, Ilka
Boni, Claudette
Buehren, Kathari ...
Bulant, Josef
Burghardt, Rolan ...
Chang, Xiao
Cichon, Sven
Cone, Roger D.
Courtet, Philipp ...
Crow, Scott
Crowley, James J ...
Danner, Unna N.
de Zwaan, Martin ...
Dedoussis, Georg ...
DeSocio, Janiece ...
Dick, Danielle M ...
Dikeos, Dimitris
Dina, Christian
Djurovic, Srdjan
Dmitrzak-Weglarz ...
Docampo-Martinez ...
Duriez, Philiber ...
Egberts, Karin
Ehrlich, Stefan
Eriksson, Johan ...
Escaramis, Georg ...
Esko, Tonu
Estivill, Xavier
Farmer, Anne
Fernandez-Aranda ...
Fichter, Manfred ...
Foecker, Manuel
Foretova, Lenka
Forstner, Andrea ...
Frei, Oleksandr
Gallinger, Steve ...
Giegling, Ina
Giuranna, Johann ...
Gonidakis, Fragi ...
Gorwood, Philip
Gratacos, Monica
Guillaume, Sebas ...
Guo, Yiran
Hakonarson, Hako ...
Hauser, Joanna
Havdahl, Alexand ...
Hebebrand, Johan ...
Helder, Sietske ...
Herms, Stefan
Herpertz-Dahlman ...
Herzog, Wolfgang
Hinney, Anke
Huebel, Christop ...
Hudson, James I.
Imgart, Hartmut
Jamain, Stephani ...
Janout, Vladimir
Jimenez-Murcia, ...
Jones, Ian R.
Julia, Antonio
Kalsi, Gursharan
Kaminska, Debora ...
Kaprio, Jaakko
Karhunen, Leila
Kas, Martien J. ...
Keel, Pamela K.
Kennedy, James L ...
Keski-Rahkonen, ...
Kiezebrink, Kirs ...
Klareskog, Lars
Klump, Kelly L.
Knudsen, Gun Peg ...
La Via, Maria C.
Le Hellard, Step ...
Leboyer, Marion
Li, Dong
Lilenfeld, Lisa
Lin, Bochao
Lissowska, Jolan ...
Luykx, Jurjen
Magistretti, Pie ...
Maj, Mario
Marsal, Sara
Marshall, Christ ...
Mattingsdal, Mor ...
Meulenbelt, Ingr ...
Micali, Nadia
Mitchell, Karen ...
Monteleone, Ales ...
Monteleone, Palm ...
Myers, Richard
Navratilova, Mar ...
Ntalla, Ionna
O'Toole, Julie K ...
Ophoff, Roel A.
Padyukov, Leonid
Pantel, Jacques
Papezova, Hana
Pinto, Dalila
Raevuori, Anu
Ramoz, Nicolas
Reichborn-Kjenne ...
Ricca, Valdo
Ripatti, Samuli
Ripke, Stephan
Ritschel, Franzi ...
Roberts, Marion
Rotondo, Alessan ...
Rujescu, Dan
Rybakowski, Fili ...
Scherag, Andre
Scherer, Stephen ...
Schmidt, Ulrike
Scott, Laura J.
Seitz, Jochen
Silen, Yasmina
Slachtova, Lenka
Slagboom, P. Eli ...
Slof-Op 't Landt ...
Slopien, Agniesz ...
Sorbi, Sandro
Swiatkowska, Bea ...
Tortorella, Alfo ...
Tozzi, Federica
Treasure, Janet
Tsitsika, Artemi ...
Tyszkiewicz-Nwaf ...
Tziouvas, Konsta ...
van Elburg, Anne ...
van Furth, Eric ...
Walton, Esther
Widen, Elisabeth
Zerwas, Stephani ...
Zipfel, Stephan
Bergen, Andrew W ...
Boden, Joseph M.
Brandt, Harry
Crawford, Steven
Halmi, Katherine ...
Horwood, L. John
Johnson, Craig
Kaplan, Allan S.
Kaye, Walter H.
Mitchell, James ...
Olsen, Catherine ...
Pearson, John F.
Pedersen, Nancy ...
Strober, Michael
Werge, Thomas
Whiteman, David ...
Woodside, D. Bla ...
Gordon, Scott
Maguire, Sarah
Larsen, Janne T.
Parker, Richard
Petersen, Liselo ...
Jordan, Jennifer
Kennedy, Martin
Wade, Tracey D.
Birgegard, Andre ...
Lichtenstein, Pa ...
Landén, Mikael, ...
Martin, Nicholas ...
Mortensen, Prebe ...
Breen, Gerome
Bulik, Cynthia M ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Neurosciences
Articles in the publication
BIOLOGICAL PSYCH ...
By the university
University of Gothenburg
Karolinska Institutet

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view