SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Palmgren Juni) srt2:(2010-2014)"

Sökning: WFRF:(Palmgren Juni) > (2010-2014)

  • Resultat 11-12 av 12
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
11.
  • Vickers, Andrew, et al. (författare)
  • Individualized Estimation of the Benefit of Radical Prostatectomy from the Scandinavian Prostate Cancer Group Randomized Trial
  • 2012
  • Ingår i: European Urology. - : Elsevier BV. - 0302-2838 .- 1873-7560. ; 62:2, s. 204-209
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Although there is randomized evidence that radical prostatectomy improves survival, there are few data on how benefit varies by baseline risk. Objective: We aimed to create a statistical model to calculate the decrease in risk of death associated with surgery for an individual patient, using stage, grade, prostate-specific antigen, and age as predictors. Design, setting, and participants: A total of 695 men with T1 or T2 prostate cancer participated in the Scandinavian Prostate Cancer Group 4 trial (SPCG-4). Intervention: Patients in SPCG-4 were randomized to radical prostatectomy or conservative management. Outcome measurements and statistical analysis: Competing risk models were created separately for the radical prostatectomy and the watchful waiting group, with the difference between model predictions constituting the estimated benefit for an individual patient. Results and limitations: Individualized predictions of surgery benefit varied widely depending on age and tumor characteristics. At 65 yr of age, the absolute 10-yr risk reduction in prostate cancer mortality attributable to radical prostatectomy ranged from 4.5% to 17.2% for low-versus high-risk patients. Little expected benefit was associated with surgery much beyond age 70. Only about a quarter of men had an individualized benefit within even 50% of the mean. A limitation is that estimates from SPCG-4 have to be applied cautiously to contemporary patients. Conclusions: Our model suggests that it is hard to justify surgery in patients with Gleason 6, T1 disease or in those patients much above 70 yr of age. Conversely, surgery seems unequivocally of benefit for patients who have Gleason 8, or Gleason 7, stage T2. For patients with Gleason 6 T2 and Gleason 7 T1, treatment is more of a judgment call, depending on patient preference and other clinical findings, such as the number of positive biopsy cores and comorbidities. 
  •  
12.
  • Wienke, Andreas, et al. (författare)
  • A bivariate survival model with compound Poisson frailty
  • 2010
  • Ingår i: Statistics in Medicine. - : Wiley. - 0277-6715 .- 1097-0258. ; 29:2, s. 275-283
  • Tidskriftsartikel (refereegranskat)abstract
    • A correlated frailty model is suggested for analysis of bivariate time-to-event data. The model is an extension of the correlated power variance function (PVF) frailty model (correlated three-parameter frailty model) (J. Epidemiol. Biostat. 1999; 4:53-60). It is based on a bivariate extension of the compound Poisson frailty model in univariate survival analysis (Ann. Appl. Probab. 1992; 4:951-972). It allows for a non-susceptible fraction (of zero frailty) in the population, overcoming the common assumption in survival analysis that all individuals are susceptible to the event under study. The model contains the correlated gamma frailty model and the correlated inverse Gaussian frailty model as special cases. A maximum likelihood estimation procedure for the parameters is presented and its properties are studied in a small simulation study. This model is applied to breast cancer incidence data of Swedish twins. The proportion of women susceptible to breast cancer is estimated to be 15 per cent.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 11-12 av 12
Typ av publikation
tidskriftsartikel (10)
forskningsöversikt (1)
bokkapitel (1)
Typ av innehåll
refereegranskat (12)
Författare/redaktör
Palmgren, Juni (11)
Adami, Hans Olov (7)
Holmberg, Lars (4)
Bill-Axelson, Anna (4)
Garmo, Hans (4)
Groop, Leif (3)
visa fler...
Steineck, Gunnar, 19 ... (3)
Pedersen, Nancy L (3)
Ripatti, Samuli (3)
Ploner, Alexander (3)
Eloranta, Sandra (2)
Häggman, Michael (2)
Dillner, Joakim (2)
Hall, Per (2)
Sparén, Pär (2)
Sundström, Karin (2)
Andersson, Swen-Olof ... (2)
Litton, Jan-Eric (2)
Sullivan, Patrick F. (2)
Gronberg, Henrik (2)
Pershagen, Göran (1)
Franks, Paul (1)
Andreassen, Ole A (1)
Kere, Juha (1)
Stattin, Pär (1)
Johansson, Jan-Erik (1)
Melbye, Mads (1)
Wiklund, Fredrik (1)
Grönberg, Henrik (1)
Andren, Ove, 1963- (1)
Holmberg, Erik, 1951 (1)
Lissner, Lauren, 195 ... (1)
Klareskog, Lars (1)
Johansson, Eva (1)
Lichtenstein, Paul (1)
Almqvist, Catarina (1)
Almgren, Peter (1)
Magnusson, Patrik K ... (1)
Ingelsson, Erik (1)
Surakka, Ida (1)
Ding, Bo (1)
Kaprio, Jaakko (1)
Andersson, Sonia (1)
Peltonen, Leena (1)
Maeurer, Markus (1)
Michaëlsson, Karl, 1 ... (1)
Tybring, Gunnel (1)
Lindgren, Anders, 19 ... (1)
Spjuth, Ola, 1977- (1)
Johansson, Jan-Erik, ... (1)
visa färre...
Lärosäte
Karolinska Institutet (10)
Göteborgs universitet (7)
Uppsala universitet (7)
Stockholms universitet (5)
Lunds universitet (5)
Örebro universitet (4)
visa fler...
Umeå universitet (2)
Linköpings universitet (2)
Chalmers tekniska högskola (1)
visa färre...
Språk
Engelska (12)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (10)
Naturvetenskap (4)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy