| 11. |
- Sundström, Johan, Professor, 1971-, et al.
(författare)
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Weight gain and blood pressure
- 2020
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Ingår i: Journal of Hypertension. - : Lippincott Williams & Wilkins. - 0263-6352 .- 1473-5598. ; 38:3, s. 387-394
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Although the causality of the obesity—hypertension association is established, the potential for prevention is not. We hypothesized that weight gain between early adulthood and mid-life is associated with higher mid-life blood pressure.METHODS: We investigated the hypothesis using a large contemporaneous population-based mid-life cohort of men and women aged 50-64 years. Recalled body weight at age 20 years was self-reported, and mid-life body weight and office blood pressures were measured in accordance with a detailed protocol.RESULTS: On average, men had gained 14.9 (95% CI 14.6-15.2) kg of weight, and women 14.6 (95% CI 14.4-14.9) kg, between age 20 years and the mid-life examination, corresponding to 0.40 (95% CI 0.39-0.41) kg/year for men and women. Both weight at age 20 years and weight at the mid-life examination were associated with mid-life blood pressures. On average, a 10 kg weight increase between age 20 years and mid-life was associated with 2.2 (95% CI 0.9-3.5) mmHg higher systolic and 1.7 (95% CI 0.9-2.5) mmHg higher diastolic mid-life blood pressure in men, and 3.2 (2.5-4.0) mmHg higher systolic and 2.4 (1.9-2.9) mmHg higher diastolic mid-life blood pressure in women. Mid-life weight was more closely associated than weight at age 20 years with mid-life blood pressure. For a given mid-life weight, blood pressure was higher in persons with higher weight gain from age 20 years.CONCLUSION: In sum, weight gain between early adulthood and mid-life was associated with higher mid-life blood pressure. The magnitude of the association indicates a potentially great public health impact of strategies to prevent weight gain throughout adulthood.
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| 12. |
- Aboulfadl, Hisham, 1986, et al.
(författare)
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Alkali Dispersion in (Ag,Cu)(In,Ga)Se2 Thin Film Solar Cells - Insight from Theory and Experiment
- 2021
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Ingår i: ACS Applied Materials & Interfaces. - : American Chemical Society (ACS). - 1944-8252 .- 1944-8244. ; 13:6, s. 7188-7199
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Tidskriftsartikel (refereegranskat)abstract
- Silver alloying of Cu(In,Ga)Se2 absorbers for thin film photovoltaics offers improvements in open-circuit voltage, especially when combined with optimal alkali-treatments and certain Ga concentrations. The relationship between alkali distribution in the absorber and Ag alloying is investigated here, combining experimental and theoretical studies. Atom probe tomography analysis is implemented to quantify the local composition in grain interiors and at grain boundaries. The Na concentration in the bulk increases up to ∼60 ppm for [Ag]/([Ag] + [Cu]) = 0.2 compared to ∼20 ppm for films without Ag and up to ∼200 ppm for [Ag]/([Ag] + [Cu]) = 1.0. First-principles calculations were employed to evaluate the formation energies of alkali-on-group-I defects (where group-I refers to Ag and Cu) in (Ag,Cu)(In,Ga)Se2 as a function of the Ag and Ga contents. The computational results demonstrate strong agreement with the nanoscale analysis results, revealing a clear trend of increased alkali bulk solubility with the Ag concentration. The present study, therefore, provides a more nuanced understanding of the role of Ag in the enhanced performance of the respective photovoltaic devices.
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| 13. |
- Adler, Karl, et al.
(författare)
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Digital Soil Mapping of Cadmium: Identifying Arable Land for Producing Winter Wheat with Low Concentrations of Cadmium
- 2023
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Ingår i: Agronomy. - : MDPI AG. - 2073-4395. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- Intake of cadmium (Cd) via vegetable food poses a possible health risk. Cereals are one of the major sources of Cd, and the Cd concentration in the soil has a great effect on the levels in the grain. The aim of the study was to produce decision support for identification of areas suitable for low-Cd winter wheat production in the form of a detailed digital soil map covering an important agricultural region in southern Sweden. A two-step approach was used: (1) we increased the number of soil Cd observations by combining two sets of soil samples, one with laboratory Cd analyses (304 samples) and one with predicted Cd from a portable x-ray fluorescent (PXRF) sensor (2097 samples); and (2) a digital soil mapping (DSM) model (gradient boosting regression) was calibrated on all 2401 soil samples to create a soil Cd concentration map using a number of covariates, of which airborne gamma ray data was identified as the most important. In the first step, cross-validation of the PXRF model obtained a model efficiency (E) of 0.82 and mean absolute error (MAE) of 0.08 mg kg(-1). The DSM model had an E of 0.69 and MAE of 0.11 mg kg(-1). The map of predicted soil Cd concentrations were compared against 307 winter wheat (Triticum aestivum L.) grain samples with laboratory-analyzed Cd concentrations. Areas in the map with low soil Cd concentrations had a high frequency of lower grain Cd concentrations. The map thus seemed to have potential for finding areas suitable for production of low-Cd winter wheat; e.g., for baby food.
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| 14. |
- Ahlström, Gerd, et al.
(författare)
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Collaboration and guidelines for the coordination of health care for frail older persons with intellectual disability : A national survey of nurses working in municipal care
- 2021
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Ingår i: Nursing Open. - : Wiley. - 2054-1058. ; 8:3, s. 1369-1379
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Tidskriftsartikel (refereegranskat)abstract
- Aims: To describe and compare perceptions of collaboration between care providers on the part of three groups of Registered Nurses working in municipal care and having particular responsibility concerning the care of frail older people with intellectual disability (ID); and, furthermore, to investigate the presence of and compliance with guidelines for the coordination of care. Design: National survey study with cross-sectional design. Methods: Nurses (N = 110) with key positions concerning people with ID answered a national questionnaire about collaboration, guidelines and coordinated individual plans. Descriptive and comparative statistical analyses were applied. Results: The meetings on cooperation and coordination of interventions were attended most frequently by nurses, and least frequently by social workers. The nurses were overall satisfied with the collaboration but perceived shortcomings in the case of inpatient and outpatient psychiatric care. Only in about half of the meetings for making care plans participated the people with intellectual disability and next of kin.
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| 15. |
- Akin, Erdal, et al.
(författare)
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Segment Anything Model (SAM) Meets Object Detected Box Prompts
- 2024
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Ingår i: 2024 IEEE International Conference on Industrial Technology (ICIT). - : Institute of Electrical and Electronics Engineers (IEEE). - 9798350340266 - 9798350340273
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Konferensbidrag (refereegranskat)abstract
- Segmenting images is an intricate and exceptionally demanding field within computer vision. Instance Segmentation is one of the subfields of image segmentation that segments objects on a given image or video. It categorizes the class labels according to individual instances, ensuring that distinct instance markers are assigned to each occurrence of the same object class, even if multiple instances exist. With the development of computer systems, segmentation studies have increased very rapidly. One of the state-of-the-art algorithms recently published by Meta AI, which segments everything on a given image, is called the Segment Anything Model (SAM). Its impressive zero-shot performance encourages us to use it for diverse tasks. Therefore, we would like to leverage the SAM for an effective instance segmentation model. Accordingly, in this paper, we propose a hybrid instance segmentation method in which Object Detection algorithms extract bounding boxes of detected objects and load SAM to produce segmentation, called Box Prompted SAM (BP-SAM). Experimental evaluation of the COCO2017 Validation dataset provided us with promising performance.
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| 16. |
- Akin, Erdal, et al.
(författare)
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Segment Anything Model (SAM) Meets Object Detected Box Prompts
- 2024
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Konferensbidrag (refereegranskat)abstract
- Segmenting images is an intricate and exceptionally demanding field within computer vision. Instance Segmentation is one of the subfields of image segmentation that segments objects on a given image or video. It categorizes the class labels according to individual instances, ensuring that distinct instance markers are assigned to each occurrence of the same object class, even if multiple instances exist. With the development of computer systems, segmentation studies have increased very rapidly. One of the state-of-the-art algorithms recently published by Meta AI, which segments everything on a given image, is called the Segment Anything Model (SAM). Its impressive zero-shot performance encourages us to use it for diverse tasks. Therefore, we would like to leverage the SAM for an effective instance segmentation model. Accordingly, in this paper, we propose a hybrid instance segmentation method in which Object Detection algorithms extract bounding boxes of detected objects and load SAM to produce segmentation, called Box Prompted SAM (BP-SAM). Experimental evaluation of the COCO2017 Validation dataset provided us with promising performance.
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| 17. |
- Alawadi, Sadi, 1983-, et al.
(författare)
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A Federated Interactive Learning IoT-Based Health Monitoring Platform
- 2021
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Ingår i: New Trends in Database and Information Systems. - Cham : Springer. ; , s. 235-246, s. 235-246
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Konferensbidrag (refereegranskat)abstract
- Remote health monitoring is a trend for better health management which necessitates the need for secure monitoring and privacy-preservation of patient data. Moreover, accurate and continuous monitoring of personal health status may require expert validation in an active learning strategy. As a result, this paper proposes a Federated Interactive Learning IoT-based Health Monitoring Platform (FIL-IoT-HMP) which incorporates multi-expert feedback as ‘Human-in-the-loop’ in an active learning strategy in order to improve the clients’ Machine Learning (ML) models. The authors have proposed an architecture and conducted an experiment as a proof of concept. Federated learning approach has been preferred in this context given that it strengthens privacy by allowing the global model to be trained while sensitive data is retained at the local edge nodes. Also, each model’s accuracy is improved while privacy and security of data has been upheld.
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| 18. |
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| 19. |
- Bengtsson, Eva, et al.
(författare)
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CD163+ macrophages are associated with a vulnerable plaque phenotype in human carotid plaques
- 2020
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- Macrophages are a functionally heterogeneous group of immune cells abundant in atherosclerotic plaques. Macrophages expressing CD163 are associated with intraplaque hemorrhage and have previously been considered atheroprotective. However, in a recent study CD163-deficient atherosclerotic ApoE−/− mice exhibited smaller and less complex plaques, suggesting a proatherogenic role of CD163. Previous smaller studies on CD163+ macrophages and plaque stability in humans have yielded diverging results. Here we assessed the association of CD163+ cells to plaque vulnerability in a large cohort of human carotid plaques. CD163 protein expression was analyzed by immunohistochemistry in 200 human carotid plaques removed by endarterectomy from 103 patients with and 93 patients without cerebrovascular symptoms. Furthermore, CD163 mRNA expression was analyzed in 66 of the plaques. Both protein and mRNA expression of CD163 was higher in plaques from symptomatic patients and in plaques with high vulnerability index. CD163+ macrophages were primarily found in shoulder regions and in the center of the plaques. The present data show that CD163 is associated with increased plaque vulnerability in human carotid plaques, supporting the notion that CD163+ macrophages could contribute to clinical events.
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| 20. |
- Berg, Ingrid L., et al.
(författare)
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MutS alpha deficiency increases tolerance to DNA damage in yeast lacking postreplication repair
- 2020
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Ingår i: DNA Repair. - : Elsevier BV. - 1568-7864 .- 1568-7856. ; 91-92
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Tidskriftsartikel (refereegranskat)abstract
- By combining mutations in DNA repair genes, important and unexpected interactions between different repair pathways can be discovered. In this study, we identified a novel link between mismatch repair (MMR) genes and postreplication repair (PRR) in Saccharomyces cerevisiae. Strains lacking Rad5 (HLTF in mammals), a protein important for restarting stalled replication forks in the error-free PRR pathway, were supersensitive to the DNA methylating agent methyl methanesulfonate (MMS). Deletion of the mismatch repair genes, MSH2 or MSH6, which together constitutes the MutS alpha complex, partially suppressed the MMS super-sensitivity of the rad5 Delta, strain. Deletion of MSH2 also suppressed the MMS sensitivity of mms2 Delta, which acts together with Rad5 in error-free PRR. However, inactivating the mismatch repair genes MSH3 and MLH1 did not suppress rad5 Delta, showing that the suppression was specific for disabling MutS alpha. The partial suppression did not require translesion DNA synthesis (REV1, REV3 or RAD30), base excision repair (MAGI) or homologous recombination (RAD51). Instead, the underlying mechanism was dependent on RAD52 while independent of established pathways involving RAD52, like single-strand annealing and break-induced replication. We propose a Rad5- and Rad51-independent template switch pathway, capable of compensating for the loss of the error-free template-switch subpathway of postreplication repair, triggered by the loss of MutS alpha.
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